问题：请帮我查下面这篇文献的作者及摘要!一定有分加！不过要快！谢谢！
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提问：hong_shou
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版块：有机化学问题(jimuwei,fpcwin1211,netpanda,yjgzfl,Ftian,)
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时间：2005-11-19 16:24:39 编辑加入/取消收藏订制/取消短消息举报该贴

请帮我查到下面这篇文献的作者及摘要！我现在定文章要用，请你一定要帮我呀！
Chemical & Pharmaceutical Bulletin, 30(12), 4258-67; 1982

回复人：木木,▲ () 时间：2005-11-19 17:56:27 编辑

1楼

Studies on antitumor agents. V. Syntheses and antitumor activities of 5-fluorouracil derivatives. Yamashita,Junichi; Yamawaki, Ichiro; Ueda, Shuichi; Yasumoto, Mitsugi; Unemi, Norio; Hashimoto, Sadao. Res. Lab., Taiho Pharm. Co., Ltd., Tokushima, Japan. Chemical & Pharmaceutical Bulletin (1982), 30(12), 4258-67. CODEN:CPBTAL ISSN: 0009-2363. Journal written in English. CAN 98:160665 AN 1983:160665 CAPLUS (Copyright (C)2005 ACS on SciFinder (R))
Abstract
Six types of 5-fluorouracil (5-FU) derivs. were synthesized; namely, 2,4-di-O-substituted, 2-O-substituted,4-O-substituted, 1,3-disubstituted, 1-substituted and 3-substituted compds. Thus, 2,4-dichloro-5-fluoropyrimidine was treated with BuONa in BuOH to give 2,4-dibutoxy-5-fluoropyrimidine. After oral administration of these compds. to rats,the blood levels of 5-FU were detd. Among O-substituted derivs., a 4-O-substituted deriv. was most easily activated to 5-FU and 2-O-substituted derivs. were next most easily activated. Among N-substituted derivs., acyl and sulfonyl
derivs. showed the highest 5-FU releasing abilities and 1-alkoxymethyl substituted derivs. showed low ability. N-Alkyl
substituted derivs. were not activated to 5-FU. Several compds. which gave higher blood levels of 5-FU than thatobtained with 1-(tetrahydro-2-furyl)-5-fluorouracil (Thf-FU), as well as same related compds., were selected and their antitumor activities were examd. The 2-O-substituted derivs., 2-butoxy-5-fluoro-4(1H)-pyrimidone and
2-benzyloxy-5-fluoro-4(1H)-pyrimidone, were as effective as Thf-FU. The activities of 2,4-di-O-substituted derivs.,2,4-dibutoxy-5-fluoropyrimidine and 2,4-dibenzyloxy-5-fluoropyrimidine, against Ehrlich carcinoma and against sarcoma 180, resp., were the same as those of Thf-FU. The 1-substituted derivs., 1-ethoxymethyl-5-fluorouracil and 1-(1-ethoxy-1-phenylmethyl)-5-fluorouracil, were found to be as effective as Thf-FU.

回复人：hong_shou,▲ (我想在有机化学的大海中畅游!) 时间：2005-11-19 18:15:42 编辑	2楼
谢谢！兄弟，有没办法搞到全文？？

回复人：木木,▲ () 时间：2005-11-19 18:46:07 编辑	3楼
呵呵，全文就没办法啦

回复人：hong_shou,▲ (我想在有机化学的大海中畅游!) 时间：2005-11-19 18:53:43 编辑	4楼
哦！谢谢！对了，我都不知道怎么在网络上查CA！可以教我吗？

回复人：木木,▲ () 时间：2005-11-19 19:46:33 编辑	5楼
都是限ip的吧，如果你那里可以查，学学应该不是什么难事。

回复人：hong_shou,▲ (我想在有机化学的大海中畅游!) 时间：2005-11-20 08:51:02 编辑	6楼
哦！我这里不能查！谢谢！！

回复人：wenchunlin,▲▲▲ (欢迎光临我的论坛http://www.happychem.com.cn/bbs) 时间：2005-11-20 09:25:35 编辑	7楼
有时间找我咯！我给你传ccd2004来！可以ca检索！

得分人：木木-3,

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