问题：问一下大家，就是什么三苯基磷钯催化剂和二苯基磷氯化钯的那些催化剂有什么的不同啊？
类型：求助 (悬赏分:3分)
提问：pirate1012
等级：▲
版块：有机化学问题(jimuwei,fpcwin1211,netpanda,yjgzfl,Ftian,)
信誉：73%
回复：5
阅读：1304
时间：2006-02-19 23:34:59 编辑加入/取消收藏订制/取消短消息举报该贴

问一下大家，就是什么三苯基磷钯催化剂和二苯基磷氯化钯的那些催化剂有什么的不同啊？
还有其他的钯催化剂有什么的不同处啊？？？
谢谢

回复人：upstart,★ (药物设计及合成,感兴趣精细化工) 时间：2006-02-20 06:21:39 编辑

1楼

The Palladium catalysts like the two catalyst you mentioned above are for Suzuki coupling reaction and Hech reaction and Sonogashira Coupling.Recently, many new ligands of Palladium catalysts have been reported and these reported new palladium catalysts gives higher yield and make reactions work for even hindered substrates. Some new catalysts just need quite mild reaction condition(room temperature).

What kind of reaction do you want to do using Pd(PPH3)3 and PdCl2(PPH3)2? I would like to give you more papers regarding your reactions.

回复人：upstart,★ (药物设计及合成,感兴趣精细化工) 时间：2006-02-20 06:31:58 编辑	2楼
For Suzuki coupling reaction and Hech reaction and Sonogashira Coupling, you can find the references from http://www.organic-chemistry.org/ I did these reactions and collected most of recent publications regarding the 3 reactions using Pd catalyst. If you have any problems, please let me know.

回复人：pirate1012,▲ (我爱化学) 时间：2006-02-20 12:55:30 编辑	3楼
谢谢你，我作的应该是still偶联反应吧，先用丁基锂拔氢，然后用三丁基氯化锡，和然后又用钯催化剂和其他溴代物反应，但是其他文献用的是lda拔氢，不知道我这个用丁基锂能否有影响

回复人：upstart,★ (药物设计及合成,感兴趣精细化工) 时间：2006-02-20 13:33:54 编辑

4楼

Stille Coupling

The Stille Coupling is a versatile C-C bond forming reaction between stannanes and halides or pseudohalides, with very few limitations on the R-groups. Well-elaborated methods allow the preparation of different products from all of the combinations of halides and stannanes depicted below. The main drawback is the toxicity of the tin compounds used, and their low polarity, which makes them poorly soluble in water. Stannanes are stable, but boronic acids and their derivatives undergo much the same chemistry in what is known as the Suzuki Coupling. Improvements in the Suzuki Coupling may soon lead to the same versatility without the drawbacks of using tin compounds.

Synthesis of Carotenoids and Retinoids: Novel Approaches involving the Stille Reaction as a Key Step

Recent Literature

Stille Coupling Made Easier - The Synergic Effect of Copper(I) Salts and the Fluoride Ion
S. P. H. Mee, V. Lee, J. E. Baldwin, Angew. Chem., 2004, 116, 1152-1156.

Highly chemoselective coupling of allenylstannanes with organic iodides promoted by Pd(PPh3)4/LiCl: an efficient method for the synthesis of substituted allenes
C.-W. Huang, M. Shanmugasundaram, H.-M. Chang, C.-H. Cheng, Tetrahedron, 2003, 59, 3635-3641.

Palladium-Catalyzed Coupling of Allylic Acetates with Aryl- and Vinylstannanes
L. Del Valle, J. K. Stille, L. S. Hegedus, J. Org. Chem, 1990, 55, 3019-3023.

Palladium-Catalyzed Chemoselective Cross-Coupling of Acyl Chlorides and Organostannanes
R. Lerebours, A. Camacho-Soto, C. Wolf, J. Org. Chem., 2005, 70, 8601-8604.

回复人：thinkpear,▲ (化学新手，来这里向大家学习学习) 时间：2006-03-02 16:58:44 编辑	5楼
我做的是heck反应不知道有没有什么最新的文献 upstart老兄

问题讨论没有结束...

您尚未进入本论坛,登录之后才可以回贴

5msec