问题：请教这个怎样合成！！！
类型：求助 (悬赏分:3分)
提问：pothon
等级：▲
版块：有机化学问题(jimuwei,fpcwin1211,netpanda,yjgzfl,Ftian,)
信誉：100%
回复：14
阅读：2949
时间：2006-03-21 10:50:00 编辑加入/取消收藏订制/取消短消息举报该贴

以丙酮为原料合成3－二甲基丁酸，谢谢！！

回复人：chemsolve,▲▲ (expert in OLED and PLED) 时间：2006-03-21 14:07:06 编辑	1楼
3－二甲基丁酸??? is it right?

回复人：hzqbamboo,▲ (化学操作工) 时间：2006-03-21 14:46:05 编辑	2楼
3－二甲基丁酸???

回复人：聚聚,▲ () 时间：2006-03-21 16:44:56 编辑	3楼
(3－二甲基丁酸)？说错了吧？标准命名？

回复人：david_zhan,★★ () 时间：2006-03-21 16:48:32 编辑	4楼
是不是3，3-二甲基丁酸？

回复人：pothon,▲ (Chemistry is amazing!!!) 时间：2006-03-22 12:34:33 编辑	5楼
不好意思是3，3－二甲基丁酸！！！大侠继续！！！

回复人：pothon,▲ (Chemistry is amazing!!!) 时间：2006-03-23 11:05:23 编辑	6楼
再请大侠帮帮手！！！

回复人：ecustlian,▲▲▲ (相互学习,共同提高) 时间：2006-03-23 18:33:05 编辑

7楼

Ref. 1 116382; Journal; Poite,M.; Metzger,J.; BSCFAS; Bull. Soc. Chim. Fr.; FR; 1962; 2078-2085.
Ref. 2 3882420; Journal; Zweifel; Backlund; JACSAT; J. Am. Chem. Soc.; 99; 1977; 3184.
Ref. 3 2978825; Journal; Ispiryan et al.; AYKZAN; Arm. Khim. Zh.; 25; 1972; 313,315, 316; Chem.Abstr.; 77; 100623p; 1972.
Ref. 4 3997696; Journal; Fernandez Gonzalez et al.; ANQUBU; An. Quim.; 71; 1975; 208,209.
Ref. 5 4049511; Journal; Becker et al.; JACSAT; J. Am. Chem. Soc.; 97; 1975; 850.
Ref. 6 4095794; Journal; Syper et al.; ROCHAC; Rocz. Chem.; 46; 1972; 849,850, 852.
Ref. 7 3396891; Journal; Zborucki; Wajcht; ROCHAC; Rocz. Chem.; 46; 1972; 897,899.
Ref. 8 4098906; Patent; Phillips Petroleum Co.; US 3956411; 1976; Chem.Abstr.; EN; 85; 123318.
Ref. 9 4006217; Journal; Bock et al.; JACSAT; J. Am. Chem. Soc.; 96; 1974; 2814,2823.
Ref. 10 1187760; Journal; Hedlund-Stoltz; ARKEAD; Ark. Kemi; 27; 1967; 485,488.
Ref. 11 5211259; Journal; Dubois et al.; BSCFAS; Bull. Soc. Chim. Fr.; 1967; 1150.
Ref. 12 5820; Journal; Iwasaki,S.; Schaffner,K.; HCACAV; Helv. Chim. Acta; GE; 51; 1968; 557-561.
Ref. 13 5229852; Journal; Oehme; Schellenberger; CHBEAM; Chem. Ber.; 101; 1968; 1499,1507.

回复人：pothon,▲ (Chemistry is amazing!!!) 时间：2006-03-24 14:49:52 编辑	8楼
请问7楼的是什么意思呢，我看不懂，可否解释一下呢？？？？谢谢！！！

回复人：gong_1,▲▲ () 时间：2006-03-24 18:02:33 编辑	9楼
呵呵,楼上的给你了合成的的相关文献,你自己去查了,他能做的已经做了

回复人：Ace,▲ (我为合成疯狂！) 时间：2006-03-24 18:41:45 编辑	10楼
你可以按以上的文献做成的，你自已去查吧！

回复人：aichenw,▲ () 时间：2006-03-25 08:17:29 编辑	11楼
7楼的太强了！佩服！

回复人：tangyyer,★★★★★ (有空来逛逛my blog: http://tangyyer.blog.hexun.com) 时间：2006-03-25 08:50:39 编辑

12楼

给你一个更详细的：Bhat, Narayan G.; Caga-Anan, Zerremi; Leija, Reynaldo. A novel synthesis of (Z)-2-(1-trimethylgermyl-1-alkenyl)-1,3,2-dioxaborinanes and their conversion into carboxylic acids. Tetrahedron Letters (2005), 46(31), 5109-5111. CODEN: TELEAY ISSN:0040-4039. CAN 143:248457 AN 2005:567717 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Zaidlewicz, M.; Krzeminski, M. Product subclass 38: trialkylboranes. Science of Synthesis (2004), 6 1097-1215. CODEN: SSCYJ9 AN 2005:329447 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Prakash, Indra; Augustine, Robert L.; Tanielyan, Setrak K. Synthesis of 3,3-dimethylbutyraldehyde by the reduction of 3,3-dimethylbutyric acid. U.S. Pat. Appl. Publ. (2004), 4 pp. CODEN: USXXCO US 2004210094 A1 20041021 CAN 141:349815 AN 2004:878205 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Jackman, Dennis E. Process for preparing 3,3-dimethylbutyric acid from the ketazine formation of trimethylpyruvic acid and hydrazine hydrate followed by reduction of the ketazine with hydrazine hydrate and a base. U.S. Pat. Appl. Publ. (2003), 5 pp. CODEN: USXXCO US 2003149302 A1 20030807 CAN 139:149331 AN 2003:610114 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Lu, Xin; Cai, Junlan; Kong, Hongwei; Wu, Ming; Hua, Ruixiang; Zhao, Mingyue; Liu, Jianfu; Xu, Guowang. Analysis of Cigarette Smoke Condensates by Comprehensive Two-Dimensional Gas Chromatography/Time-of-Flight Mass Spectrometry I Acidic Fraction. Analytical Chemistry (2003), 75(17), 4441-4451. CODEN: ANCHAM ISSN:0003-2700. CAN 139:225596 AN 2003:532935 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Boyle, Timothy J.; Andrews, Nicholas L.; Alam, Todd M.; Rodriguez, Mark A.; Santana, Jessica M.; Scott, Brian L. Crystallographic characterization of the esterification pathway of Group V alkoxides. Polyhedron (2002), 21(23), 2333-2345. CODEN: PLYHDE ISSN:0277-5387. CAN 138:162542 AN 2002:838397 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Silva, Christopher J. Positive selection of transformants by auxotroph complementation with enzymatic precursor conversion. PCT Int. Appl. (2001), 51 pp. CODEN: PIXXD2 WO 2001077366 A1 20011018 CAN 135:314428 AN 2001:763228 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Ebner, Jerry R.; Guo, Zhi; Hershman, Arnold; Klein, Loraine M.; Mcghee, William D.; Paster, Mark D.; Prakash, Indra. Process for the preparation of 3,3-dimethylbutanal. PCT Int. Appl. (2001), 156 pp. CODEN: PIXXD2 WO 2001002332 A2 20010111 CAN 134:102525 AN 2001:31440 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Stelzer, Uwe. Single-step process for the synthesis of 3,3-dimethylbutyric acid from trimethylpyruvic acid. Eur. Pat. Appl. (1998), 6 pp. CODEN: EPXXDW EP 884299 A1 19981216 CAN 130:52148 AN 1999:3405 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Dagnac, Thierry; Guillot, Jean-Michel; Le Cloirec, Pierre. A methodological approach to N,N-dialkylamide thermal degradation at low temperatures. Journal of Analytical and Applied Pyrolysis (1996), 37(1), 33-47. CODEN: JAAPDD ISSN:0165-2370. CAN 125:247066 AN 1996:533274 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Tsuruoka, Kuniaki; Sei, Nobuhiko; Takahashi, Fujio. Lubricating oil compositions with high stability to thermal oxidation and high viscosity indexes. Jpn. Kokai Tokkyo Koho (1994), 14 pp. CODEN: JKXXAF JP 06158079 A2 19940607 Heisei. CAN 121:160620 AN 1994:560620 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Brown, Herbert C.; Kulkarni, Shekhar V.; Khanna, Vijay V.; Patil, Virendra D.; Racherla, Uday S. Organoboranes for synthesis. 14. Convenient procedures for the direct oxidation of organoboranes from terminal alkenes to carboxylic acids. Journal of Organic Chemistry (1992), 57(23), 6173-7. CODEN: JOCEAH ISSN:0022-3263. CAN 117:233412 AN 1992:633412 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Racherla, Uday S.; Khanna, Vijay V.; Brown, Herbert C. A convenient procedure for the direct conversion of terminal alkenes into carboxylic acids. Tetrahedron Letters (1992), 33(8), 1037-40. CODEN: TELEAY ISSN:0040-4039. CAN 116:193681 AN 1992:193681 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Takeshita, Akira; Tokumaru, Tooru; Tsukuda, Kinshiro; Tokumasu, Shigefumi; Kudo, Shogo. Preparation of 3,3-dimethylbutyric acid. Jpn. Kokai Tokkyo Koho (1990), 4 pp. CODEN: JKXXAF JP 02006429 A2 19900110 Heisei. CAN 112:197635 AN 1990:197635 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

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El Ali, Bassam; Bregeault, Jean Marie; Mercier, Jacqueline; Martin, Jacques; Martin, Claudine; Convert, Odile. The oxidation of ketones with a heteropoly acid, H5[PMo10V2O40], and dioxygen. Journal of the Chemical Society, Chemical Communications (1989), (13), 825-6. CODEN: JCCCAT ISSN:0022-4936. CAN 112:54455 AN 1990:54455 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Takeshita, Akira; Suzuki, Mikio; Tsukuda, Kinshiro. Simultaneous manufacture of 3,3-dimethylbutyric acid and tert-butyl chloride. Jpn. Kokai Tokkyo Koho (1988), 3 pp. CODEN: JKXXAF JP 63222130 A2 19880916 Showa. CAN 111:6927 AN 1989:406927 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Roussis, Vassilios; Gloer, Katherine B.; Wiemer, David F. A skeletal rearrangement of -(acyloxy)--keto phosphonates: studies on the formation of 2(3H)-furanones. Journal of Organic Chemistry (1988), 53(9), 2011-15. CODEN: JOCEAH ISSN:0022-3263. CAN 110:57760 AN 1989:57760 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Choi, Joong Kwon; Chang, Young Kil; Hong, Sung Yeap. Catalytic oxidation of aldehydes to carboxylic acids with hydrogen peroxide as oxidant. Tetrahedron Letters (1988), 29(16), 1967-70. CODEN: TELEAY ISSN:0040-4039. CAN 109:92392 AN 1988:492392 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Nubaryan, T. K.; Nubaryan, M. A.; Basentsyan, S. S.; Bagdasaryan, V. V.; Badishyan, A. G.; Markosyan, F. G. Statistical models for selective oxidation of paraffin hydrocarbon mixtures to monocarboxylic acids. Armyanskii Khimicheskii Zhurnal (1986), 39(11), 675-9. CODEN: AYKZAN ISSN:0515-9628. CAN 108:5560 AN 1988:5560 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Stang, Peter J.; Roberts, Kenneth A. Electrophilic additions to alkynyl tosylates. Formation of vinyl 1,1-(bis esters) and related compounds. X-ray structure determination of (E)-1-chloro-1-(tosyloxy)-3,3-dimethyl-1-butene. Journal of Organic Chemistry (1987), 52(23), 5213-17. CODEN: JOCEAH ISSN:0022-3263. CAN 107:217085 AN 1987:617085 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

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Tamao, Kohei; Kumada, Makoto; Maeda, Kimio. Silafunctional compounds in organic synthesis. 21. Hydrogen peroxide oxidation of alkenyl(alkoxy)silanes. Tetrahedron Letters (1984), 25(3), 321-4. CODEN: TELEAY ISSN:0040-4039. CAN 100:190949 AN 1984:190949 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

3,3-Dimethylbutyric acid. Jpn. Kokai Tokkyo Koho (1982), 4 pp. CODEN: JKXXAF JP 57206636 A2 19821218 Showa. CAN 98:106820 AN 1983:106820 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Brittelli, David R. Phosphite-mediated in situ carboxyvinylation: a new general acrylic acid synthesis. Journal of Organic Chemistry (1981), 46(12), 2514-20. CODEN: JOCEAH ISSN:0022-3263. CAN 95:6448 AN 1981:406448 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Yuen, George U.; Lawless, James G.; Edelson, Edward H. Quantification of monocarboxylic acids from a spark discharge synthesis. Journal of Molecular Evolution (1981), 17(1), 43-7. CODEN: JMEVAU ISSN:0022-2844. CAN 94:169881 AN 1981:169881 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Nilsson, Aasa; Carlson, Rolf. A modified procedure for the synthesis of tert-butylacetic acid. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry (1980), B34(8), 621. CODEN: ACBOCV ISSN:0302-4369. CAN 94:139167 AN 1981:139167 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Ahlbrecht, H.; Pfaff, K. 2-(N-Methylanilino) acrylonitrile, a new 2-C Michael acceptor. Synthesis (1978), (12), 897-9. CODEN: SYNTBF ISSN:0039-7881. CAN 90:121151 AN 1979:121151 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Petrov, M. L.; Bobylev, V. A.; Petrov, A. A. Addition of carboxylic acids to acetylenic thio ethers. Tezisy Dokl. Nauchn. Sess. Khim. Tekhnol. Org. Soedin. Sery Sernistykh Neftei, 14th (1976), Meeting Date 1975, 151-2. CODEN: 37RMA9 CAN 89:42363 AN 1978:442363 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

Zweifel, George; Backlund, Stephen J. Novel syntheses of monosubstituted acetic, ,-unsaturated, and ,-unsaturated acids via silylation, hydroboration, and oxidation of the ethynyl group of 1-alkynes and functionally substituted 1-alkynes. Journal of the American Chemical Society (1977), 99(9), 3184-5. CODEN: JACSAT ISSN:0002-7863. CAN 86:189136 AN 1977:189136 CAPLUS (Copyright (C) 2006 ACS on SciFinder (R))

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回复人：yp_cas,▲▲▲▲▲ (Palytoxin) 时间：2006-03-29 19:21:20 编辑	13楼
丙二酸二酯先与丙酮羰基缩合脱水后形成3，3－二甲基a,b不饱和羧算再与(CH3)2CULi或CH3Li+CuX发生1,4加成,得到的就是你想要的东东

回复人：yjgzfl,★ (研究) 时间：2006-08-25 11:59:19 编辑	14楼
已经打分了。

得分人：ecustlian-2,tangyyer-2,yp_cas-1,

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