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问题：请教一个合成。
类型：求助 (悬赏分:3分)
提问：lanyuntian
等级：▲
版块：有机化学问题(jimuwei,fpcwin1211,netpanda,yjgzfl,Ftian,)
信誉：92%
回复：12
阅读：426
时间：2006-03-21 12:58:04 编辑加入/取消收藏订制/取消短消息举报该贴

请问如何在下列结构（奥沙西泮）中接入一个－（CH2)n-COOH基团？

回复人：upstart,★ (药物设计及合成,感兴趣精细化工) 时间：2006-03-21 13:19:32 编辑	1楼
通过Cl做Heck coupling or Sonogashira Coupling

回复人：chemsolve,▲▲ (expert in OLED and PLED) 时间：2006-03-21 14:10:26 编辑	2楼
Organic Preparations and Procedures International, 10(3), 105-11; 1978

回复人：chemsolve,▲▲ (expert in OLED and PLED) 时间：2006-03-21 14:13:27 编辑	3楼
modify the oh group in the compound

回复人：upstart,★ (药物设计及合成,感兴趣精细化工) 时间：2006-03-21 14:23:52 编辑	4楼
To chemsolve: The OH is actually like carbonyl, while the carbonyl on the molecule is like OH. So you may be difficult to convert only one OH to halide in a normal way.

回复人：chemsolve,▲▲ (expert in OLED and PLED) 时间：2006-03-21 14:26:36 编辑	5楼
no, i read some papers in which the auther convert only one oh to their product.

回复人：upstart,★ (药物设计及合成,感兴趣精细化工) 时间：2006-03-21 14:29:39 编辑	6楼
Can yo tell me whick OH will be reacted?

回复人：chemsolve,▲▲ (expert in OLED and PLED) 时间：2006-03-21 14:29:52 编辑	7楼
try to use SOCl2 to modify OH then react with alchol or use carbonyl chloride to react with OH

回复人：chemsolve,▲▲ (expert in OLED and PLED) 时间：2006-03-21 14:30:41 编辑	8楼
the oh group in your pic

回复人：upstart,★ (药物设计及合成,感兴趣精细化工) 时间：2006-03-21 14:37:21 编辑	9楼
Really? Thanks. If it works as chemsolve says, it may be a route to make bromide or chloride from the OH and the bromide will provide a chance to induce CH2)n-COOH by Heck Coupling or Sonogashira Coupling. Good luck to your reaction.

回复人：lanyuntian,▲ () 时间：2006-04-12 11:27:27 编辑	10楼
已经打分了。

回复人：upstart,★ (药物设计及合成,感兴趣精细化工) 时间：2006-04-12 11:48:03 编辑	11楼
Thanks and good luck

回复人：chemsolve,▲▲ (expert in OLED and PLED) 时间：2006-04-12 11:53:47 编辑	12楼
where is my score?

得分人：upstart-1,

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