问题：lehninger的Principles of Biochemistry,生物化学原理,2004年第四版，1124页
类型：推荐
提问：Yan
等级：★
版块：生物化学(zb3,zb1,)
信誉：90%
回复：32
阅读：4418
时间：2005-03-12 08:31:27 编辑加入/取消收藏订制/取消短消息举报该贴

ftp://down@chemforum.8800.org/in/PrinciplesofBiochemistry.pdf

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[该帖子已被Yan在2005-3-12 8:46:51编辑过]

回复人：greenzhu,▲ (1) 时间：2006-03-01 11:27:51 编辑	1楼
资源不错，加0.1分

回复人：greenzhu,▲ (1) 时间：2006-03-01 11:28:11 编辑	2楼
I need it!

回复人：greenzhu,▲ (1) 时间：2006-03-01 11:28:27 编辑	3楼
inedd

回复人：greenzhu,▲ (1) 时间：2006-03-01 11:28:42 编辑	4楼
资源不错，加0.1分

回复人：greenzhu,▲ (1) 时间：2006-03-01 11:28:49 编辑	5楼
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回复人：greenzhu,▲ (1) 时间：2006-03-01 11:28:55 编辑	6楼
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回复人：laurel,▲ (喜欢选择的,选择的会是最好的yo!) 时间：2006-07-21 09:28:51 编辑	7楼
支付了积分，怎么还是不能下载？麻烦那位仁兄发一本给我吧，我的邮箱dxh2006@56.com 多谢多谢！

回复人：funly100,▲ (天然产物有机化学) 时间：2006-09-23 23:12:38 编辑	8楼
不错

回复人：jsxiaowu,▲ (为人诚恳、喜好交友、做事塌实、喜欢阅读、上网) 时间：2006-09-24 03:42:58 编辑	9楼
bu cuo

回复人：zhe999,▲ () 时间：2006-11-03 11:06:14 编辑	10楼
经典啊，可惜下不到啊

回复人：xie381,▲ () 时间：2007-06-08 17:35:36 编辑	11楼
资源不错，加0.3分

回复人：孤独的狂欢,▲ () 时间：2008-08-28 20:21:35 编辑	12楼
I need it badly!

回复人：Yan,★ (他山之石，可以攻玉) 时间：2005-03-12 08:37:49 编辑

13楼

国内沈同那本写得不错。这本没有看。
1124页，35M，第四版
第三版的介绍http://www.amazon.com/exec/obidos/ASIN/1572599316/102-4484847-3838512

部分章节目录
Lehninger Principles of Biochemistry
Fourth Edition
David L. Nelson (U. of Wisconsin–Madison)
Michael M. Cox (U. of Wisconsin–Madison)
1. The Foundations of Biochemistry
1.1 Cellular Foundations
1.2 Chemical Foundations
1.3 Physical Foundations
1.4 Genetic Foundations
1.5 Evolutionary Foundations
Distilled and reorganized from Chapters 1–3 of the previous edition, this overview
provides a refresher on the cellular, chemical, physical, genetic, and evolutionary
background to biochemistry, while orienting students toward what is unique about
biochemistry.
PART I. STRUCTURE AND CATALYSIS
2. Water
2.1 Weak Interactions in Aqueous Systems
2.2 Ionization of Water, Weak Acids, and Weak Bases
2.3 Buffering against pH Changes in Biological Systems
2.4 Water as a Reactant
2.5 The Fitness of the Aqueous Environment for Living Organisms
Includes new coverage of the concept of protein-bound water, illustrated with
molecular graphics.
3. Amino Acids, Peptides, and Proteins
3.1 Amino Acids
3.2 Peptides and Proteins
3.3 Working with Proteins
3.4 The Covalent Structure of Proteins
3.5 Protein Sequences and Evolution
Adds important new material on genomics and proteomics and their implications for
the study of protein structure, function, and evolution.
4. The Three-Dimensional Structure of Proteins
4.1 Overview of Protein Structure
4.2 Protein Secondary Structure
4.3 Protein Tertiary and Quaternary Structures
4.4 Protein Denaturation and Folding
Adds a new box on scurvy.
5. Protein Function
5.1 Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins
5.2 Complementary Interactions between Proteins and Ligands: The Immune
System and Immunoglobulins
5.3 Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and
Molecular Motors
Adds a new box on carbon monoxide poisoning
6. Enzymes
6.1 An Introduction to Enzymes
6.2 How Enzymes Work
6.3 Enzyme Kinetics as An Approach to Understanding Mechanism
6.4 Examples of Enzymatic Reactions
6.5 Regulatory Enzymes
Offers a revised presentation of the mechanism of chymotrypsin (the first reaction
mechanism in the book), featuring a two-page figure that takes students through this
particular mechanism, while serving as a step-by-step guide to interpreting any
reaction mechanism
Features new coverage of the mechanism for lysozyme including the controversial
aspects of the mechanism and currently favored resolution based on work published in
2001.
7. Carbohydrates and Glycobiology
7.1 Monosaccharides and Disaccharides
7.2 Polysaccharides
7.3 Glycoconjugates: Proteoglycans, Glycoproteins, and Glycolipids
7.4 Carbohydrates as Informational Molecules: The Sugar Code
7.5 Working with Carbohydrates
Includes new section on polysaccharide conformations.
A striking new discussion of the "sugar code" looks at polysaccharides as
informational molecules, with detailed discussions of lectins, selectins, and
oligosaccharide-bearing hormones.
Features new material on structural heteropolysaccharides and proteoglycans
Covers recent techniques for carbohydrate analysis.
8. Nucleotides and Nucleic Acids
8.1 Some Basics
8.2 Nucleic Acid Structure
8.3 Nucleic Acid Chemistry
8.4 Other Functions of Nucleotides
9. DNA-Based Information Technologies
9.1 DNA Cloning: The Basics
9.2 From Genes to Genomes
9.3 From Genomes to Proteomes
9.4 Genome Alterations and New Products of Biotechnology
Introduces the human genome. Biochemical insights derived from the human
genome are integrated throughout the text.
Tracking the emergence of genomics and proteomics, this chapter establishes DNA
technology as a core topic and a path to understanding metabolism, signaling, and
other topics covered in the middle chapters of this edition. Includes up-to-date
coverage of microarrays, protein chips, comparative genomics, and techniques in
cloning and analysis.
10. Lipids
10.1 Storage Lipids
10.2 Structural Lipids in Membranes
10.3 Lipids as Signals, Cofactors, and Pigments
10.4 Working with Lipids
Integrates new topics specific to chloroplasts and archaebacteria
Adds material on lipids as signal molecules.
11. Biological Membranes and Transport
11.1 The Composition and Architecture of Membranes
11.2 Membrane Dynamics
11.3 Solute Transport across Membranes
Includes a description of membrane rafts and microdomains within membranes,
and a new box on the use of atomic force microscopy to visualize them.
Looks at the role of caveolins in the formation of membrane caveolae
Covers the investigation of hop diffusion of membrane lipids using FRAP
(fluorescence recovery after photobleaching)
Adds new details to the discussion of the mechanism of Ca2- ATPase (SERCA
pump), revealed by the recently available high-resolution view of its structure
Explores new facets of the mechanisms of the K+ selectivity filter, brought to light
by recent high-resolution structures of the K+ channel
Illuminates the structure, role, and mechanism of aquaporins with important new
details
Describes ABC transporters, with particular attention to the multidrug transporter
(MDR1)
Includes the newly solved structure of the lactose transporter of E. coli.
12. Biosignaling
12.1 Molecular Mechanisms of Signal Transduction
12.2 Gated Ion Channels
12.3 Receptor Enzymes
12.4 G Protein-Coupled Receptors and Second Messengers
12.5 Multivalent Scaffold Proteins and Membrane Rafts
12.6 Signaling in Microorganisms and Plants
12.7 Sensory Transduction in Vision, Olfaction, and Gustation
12.8 Regulation of Transcription by Steroid Hormones
12.9 Regulation of the Cell Cycle by Protein Kinases
12.10 Oncogenes, Tumor Suppressor Genes, and Programmed Cell Death
Updates the previous edition's groundbreaking chapter to chart the continuing rapid
development of signaling research
Includes discussion on general mechanisms for activation of protein kinases in
cascades
Now covers the roles of membrane rafts and caveolae in signaling pathways,
including the activities of AKAPs (A Kinase Anchoring Proteins) and other scaffold
proteins
Examines the nature and conservation of families of multivalent protein binding
modules, which combine to create many discrete signaling pathways
Adds a new discussion of signaling in plants and bacteria, with comparison to
mammalian signaling pathways
Features a new box on visualizing biochemistry with fluorescence resonance energy
transfer (FRET) with green fluorescent protein (GFP)
PART II: BIOENERGETICS AND METABOLISM
13. Principles of Bioenergetics
13.1 Bioenergetics and Thermodynamics
13.2 Phosphoryl Group Transfers and ATP
13.3 Biological Oxidation-Reduction Reactions
Examines the increasing awareness of the multiple roles of polyphosphate
Adds a new discussion of niacin deficiency and pellagra.
14. Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
14.1 Glycolysis
14.2 Feeder Pathways for Glycolysis
14.3 Fates of Pyruvate under Anaerobic Conditions: Fermentation
14.4 Gluconeogenesis
14.5 Pentose Phosphate Pathway of Glucose Oxidation
Now covers gluconeogenesis immediately after glycolysis, discussing their
relatedness, differences, and coordination and setting up the completely new chapter
on metabolic regulation that follows
Adds coverage of the mechanisms of phosphohexose isomerase and aldolase
Revises the presentation of the mechanism of glyceraldehyde 3-phosphate
dehydrogenase.
New Chapter 15. Principles of Metabolic Regulation, Illustrated with Glucose and
Glycogen Metabolism
15.1 The Metabolism of Glycogen in Animals
15.2 Regulation of Metabolic Pathways
15.3 Coordinated Regulation of Glycolysis and Gluconeogenesis
15.4 Coordinated Regulation of Glycogen Synthesis and Breakdown
15.5 Analysis of Metabolic Control
Brings together the concepts and principles of metabolic regulation in one chapter
Concludes with the latest conceptual approaches to the regulation of metabolism,
including metabolic control analysis and contemporary methods for studying and
predicting the flux through metabolic pathways
16. The Citric Acid Cycle
16.1 Production of Acetyl-CoA (Activated Acetate)
16.2 Reactions of the Citric Acid Cycle
16.3 Regulation of the Citric Acid Cycle
16.4 The Glyoxylate Cycle
Expands and updates the presentation of the mechanism for pyruvate carboxylase.
Adds coverage of the mechanisms of isocitrate dehydrogenase and citrate
synthase.
17. Fatty Acid Catabolism
17.1 Digestion, Mobilization, and Transport of Fats
17.2 Oxidation of Fatty Acids
17.3 Ketone Bodies
Updates coverage of trifunctional protein
New section on the role of perilipin phosphorylation in the control of fat mobilization
New discussion of the role of acetyl-CoA in the integration of fatty acid oxidation
and synthesis
Updates coverage of the medical consequences of genetic defects in fatty acyl–CoA
dehydrogenases
Takes a fresh look at medical issues related to peroxisomes
18. Amino Acid Oxidation and the Production of Urea
18.1 Metabolic Fates of Amino Groups
18.2 Nitrogen Excretion and the Urea Cycle
18.3 Pathways of Amino Acid Degradation
Integrates the latest on regulation of reactions throughout the chapter, with new
material on genetic defects in urea cycle enzymes, and updated information on the
regulatory function of N-acetylglutamate synthase.
Reorganizes coverage of amino acid degradation to focus on the big picture
Adds new material on the relative importance of several degradative pathways
Includes a new description of the interplay of the pyridoxal phosphate and
tetrahydrofolate cofactors in serine and glycine metabolism
19. Oxidative Phosphorylation and Photophosphorylation
Oxidative Phosporylation
19.1 Electron-Transfer Reactions in Mitochondria
19.2 ATP Synthesis
19.3 Regulation of Oxidative Phosphorylation
19.4 Mitochondrial Genes: Their Origin and the Effects of Mutations
19.5 The Role of Mitochondria in Apoptosis and Oxidative Stress
Photosynthesis: Harvesting Light Energy
19.6 General Features of Photophosphorylation
19.7 Light Absorption
19.8 The Central Photochemical Event: Light-Driven Electron Flow
19.9 ATP Synthesis by Photophosphorylation
Adds a prominent new section on the roles of mitochondria in apoptosis and
oxidative stress
Now covers the role of IF1 in the inhibition of ATP synthase during ischemia
Includes revelatory details on the light-dependent pathways of electron transfer in
photosynthesis, based on newly available molecular structures

[该帖子已被Yan在2005-3-12 8:48:35编辑过]

回复人：Yan,★ (他山之石，可以攻玉) 时间：2005-03-12 08:47:41 编辑	14楼
有很多彩图，做的很精致。应该比沈同那本更丰富。

回复人：mipman,▲ (色谱分析和有机合成人员) 时间：2005-04-13 19:06:13 编辑	15楼
~{GkNJJGTZB[L35D~}ftp~{MxU>IOBp~}? ~{NRN^7(5GB=~}ftp~{U>5c~}.

回复人：admin,★ (论坛管理员-欢迎大家访问化学化工论坛) 时间：2005-04-13 21:43:10 编辑	16楼
怎么某些网友的帖子是乱码？

回复人：apheyh,▲ () 时间：2005-05-28 15:04:16 编辑	17楼
我也有这本，有水想要的话来信索取apheyh@gmail.com

回复人：aminium,▲▲▲ (一个普通人) 时间：2005-05-29 17:39:51 编辑	18楼
Yan兄，怎么无法下载啊？

回复人：w728,▲ () 时间：2005-06-25 00:18:35 编辑	19楼
灌水！

回复人：leoying,▲ () 时间：2005-07-21 12:08:05 编辑	20楼
我也很想要这本书，谁能告诉我哪有卖的吗?谁把下载地址告诉我，我正在考研，迫切需要这本书，可怜可怜我吧。我还要发十八个帖子才能攒够可用分。

回复人：oldwu007,▲ () 时间：2005-07-26 16:58:29 编辑	21楼
我也有一本，但是不知道是第几版，争取早日发上来让大家看看。

回复人：jic,▲ (迷茫者) 时间：2005-08-22 16:26:13 编辑	22楼
近来接触到一些生化方面的东西，觉得自己应该补补这方面的知识了。

回复人：goodmann,▲ () 时间：2005-09-24 14:55:30 编辑	23楼
我的分数还不够。能不能发给我一份？我给你加分。先谢谢啦！thisbob@163.com

回复人：hong_shou,▲ (我想在有机化学的大海中畅游!) 时间：2005-09-30 22:26:53 编辑	24楼
资源不错，加0.1分

回复人：hong_shou,▲ (我想在有机化学的大海中畅游!) 时间：2005-09-30 22:28:15 编辑	25楼
我的邮箱是:hong_shou@126.com 谢谢先

回复人：木石,▲ () 时间：2005-12-05 22:39:23 编辑	26楼
还有限制啊！看不到！郁闷～！

回复人：flychem,★ () 时间：2007-12-05 14:47:14 编辑	27楼
资源不错，加0.3分

回复人：80418278,▲ (打算学生化，随便逛逛，先来接触点前沿知识或者一些专业名词) 时间：2008-08-29 12:08:13 编辑	28楼
可以给我发一份吗？我现在只有0分，根本不可能下到 xyxuying1989@qq.com

回复人：avmhvx910,▲ () 时间：2017-03-10 09:56:26 编辑

29楼

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回复人：ulmx2349,▲ () 时间：2017-04-28 09:21:32 编辑

30楼

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