问题：有关海葵毒素的合成
类型：求助 (悬赏分:3分)
提问：xytlitu
等级：▲
版块：有机化学问题(jimuwei,fpcwin1211,netpanda,yjgzfl,Ftian,)
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回复：5
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时间：2006-03-31 10:22:46 编辑加入/取消收藏订制/取消短消息举报该贴

那位大虾知道在什末地方可以查到海葵毒素的合成的文献？谢谢！

回复人：chimeralu,★ (拼命在一线工作，大量地阅读文献.) 时间：2006-03-31 10:33:54 编辑	1楼
海葵毒素，应该很好找的。全合成的颠峰之作。

回复人：yp_cas,▲▲▲▲▲ (Palytoxin) 时间：2006-03-31 20:53:20 编辑	2楼
恩,经典天然产物全合成里一般都会涉及的,我帮你找找,你留个邮箱

回复人：yp_cas,▲▲▲▲▲ (Palytoxin) 时间：2006-03-31 22:25:57 编辑

3楼

Palitoxin (1989, 1994)
Isolated from soft corals of the Palythoa genus, palitoxin is endowed with toxic properties exceeded only by a few other substances known to man.[1] Both its structural elucidation and total synthesis posed formidable challenges to chemists. While the gross structural elucidation of palitoxin was reported independently by the groups of
Hirata[2] and Moore[3] in 1981, its total synthesis had to await several more years of intense efforts. Finally, after heroic efforts from Kishi and his group the synthesis of palitoxin carboxylic acid was published in 1989[4] and that of palitoxin itself in 1994[5] The synthesis of palitoxin holds a special place in the history of total synthesis in that palitoxin is the largest secondary metabolite to be
synthesized in the laboratory, both in terms of molecular weight and number of stereocenters. Most importantly, this mammoth endeavor led to the discovery and development of a number of useful synthetic reactions. Amongst them are the improvement of the NiCl2/CrCl2-mediated coupling reaction between iodo-olefins and aldehydes, a modified, refined method for the Suzuki palladium-catalyzed coupling reaction leading to conjugated dienes, and a new synthesis of N-acyl
ureas.

相关参考:
[1] For reviews of palytoxin, see a) R. E. Moore, Prog. Chem. Org. Nat.Prod. 1985, 48, 81 - 202; b) Y. Hirata, D. Uemura, Y. Ohizumi,
Handbook of Natural Toxins, Vol. 3 (Ed.: A. T. Tu), Marcel Dekker,
New York, 1988, p. 241.
[2] D. Uemura, K. Ueda, Y. Hirata, H. Naoki, T. Iwashita, Tetrahedron
Lett. 1981, 22, 2781 -2784.
[3] R. E. Moore, G. Bartolini, J. Am. Chem. Soc. 1981, 103, 2491- 2494.
[4] a) R. W. Armstrong, J.-M. Beau, S. H. Cheon, W. J. Christ, H.
Fujioka, W.-H. Ham, L. D. Hawkins, H. Jin, S. H. Kang, Y. Kishi,
M. J. Martinelli,W. W. McWhorter, Jr., M. Mizuno, M. Nakata, A. E.
Stutz, F. X. Talamas, M. Taniguchi, J. A. Tino, K. Ueda, J.-i. Uenishi,J. B. White, M. Yonaga, J. Am. Chem. Soc. 1989, 111, 7525- 7530;b) R. W. Armstrong, J.-M. Beau, S. H. Cheon, W. J. Christ, H.
Fujioka, W.-H. Ham, L. D. Hawkins, H. Jin, S. H. Kang, Y. Kishi,
M. J. Martinelli,W. W. McWhorter, Jr., M. Mizuno, M. Nakata, A. E.
Stutz, F. X. Talamas, M. Taniguchi, J. A. Tino, K. Ueda, J.-i. Uenishi,J. B. White, M. Yonaga, J. Am. Chem. Soc. 1989, 111, 7530 -7533. See
also
[5] E. M. Suh, Y. Kishi, J. Am. Chem. Soc. 1994, 116, 11 205 - 11206.
[6]K. C. Nicolaou, E. J. Sorensen, Classics in Total Synthesis, VCH,
Weinheim, 1996.

[该帖子已被yp_cas在2006-3-31 22:29:17编辑过]

回复人：xytlitu,▲ (我学化学) 时间：2006-04-11 23:46:24 编辑	4楼
谢谢各位了，我找到了！Classics in total synthesis

回复人：yjgzfl,★ (研究) 时间：2006-08-25 11:33:16 编辑	5楼
已经打分了。

得分人：yp_cas-2,

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