问题：请问1,3-环戊二酮怎么合成
类型：求助 (悬赏分:3分)
提问：lwqw
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版块：药物化学(jaywoo,合成小象,)
信誉：50%
回复：6
阅读：2011
时间：2006-03-31 10:29:10 编辑加入/取消收藏订制/取消短消息举报该贴

能否用乙酰氯和丁二酸在三氯化铝催化,二氯乙烷溶剂中环合

回复人：wenchunlin,▲▲▲ (欢迎光临我的论坛http://www.happychem.com.cn/bbs) 时间：2006-03-31 11:35:43 编辑

1楼

RCB_CT,129631Entry Name: 1,3-Cyclopentanedione, 9CI
Synonym(s): 3-Hydroxy-2-cyclopenten-1-
10335301,158

Chapman Hall Number: CZF79-P
CAS Registry Number: 3859-41-4

Molecular Formula: C5H6O2
Molecular Weight: 98.101
Accurate Mass: 98.03678
Percentage Composition: C 61.22%; H 6.16%; O 32.62%
Physical Description: Cryst. (butanone)
Melting Point: Mp 151-152
Other Data: Immediately turns yellow on melting

Aldrich: 17716-4
Fluka: 29730
Sigma:
RCB_CT,129632Variant: Enol-form
Chapman Hall Number: JOF27-Y
Molecular Formula: C5H6O2
Molecular Weight: 98.101
Accurate Mass: 98.03678
Percentage Composition: C 61.22%; H 6.16%; O
RCB_CT,129633Derivative: Me ether
Synonym(s): 3-Methoxy-2-cyclopenten-1-one
Chapman Hall Number: JOF28-Z
CAS Registry Number: 4683-50-5
Molecular Formula: C6H8O2
Molecular Weight: 112.128
Accurate Mass: 112.05243
Percentage Composition: C 64.27%; H 7.19%; O 28.54%
Melting Point: Mp 49-53
RCB_CT,129634Derivative: Et ether
Synonym(s): 3-Ethoxy-2-cyclopenten-1-one
Chapman Hall Number: JOF29-A
CAS Registry Number: 22627-70-9
Molecular Formula: C7H10O2
Molecular Weight: 126.155
Accurate Mass: 126.06808
Percentage Composition: C 66.65%; H 7.99%; O 25.36%
Boiling Point: Bp0.3 60-63
Density: d 1.06
Refractive Index: n20D
References:
Aldrich Library of FT-IR Spectra, 1st edn., 1985, 1, 426C, (ir)
Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 1, 701C, (nmr)
Boothe, J.H. et al., J.A.C.S., 1953, 75, 1732, (synth)
House, H.O. et al., J.O.C., 1963, 28, 27, (Me ether, synth, ir, pmr)
Cant, E., Bull. Soc. Chim. Belg., 1974, 83, 93, (Me ether, ms)
Sraga, J. et al., Synthesis, 1977, 282, (synth)
Czech. Pat., 1978, 172 020; CA, 89, 163142, (synth)
Nilsson, M., Acta Chem. Scand., Ser. B, 1981, 35, 667, (synth, bibl)
Kikami, B.B. et al., Synthesis, 1991, 176, (Et ether, synth, ir, pmr)
Fuchs, R. et al., Synthesis, 1992, 373, (synth, pmr)
Encyclopaedia of Reagents for Organic Synthesis, (ed. Paquette, L.A.), Wiley, 1995, 2, 1455-1456, (use)

[00034914-8] A20 M0

回复人：nakata,▲▲▲▲▲ () 时间：2006-03-31 19:47:49 编辑	2楼
http://v3.espacenet.com/origdoc?DB=EPODOC&IDX=US5113012&F=0&QPN=US5113012

回复人：dgrlt,▲ () 时间：2006-08-23 11:37:10 编辑	3楼
能否用丙二酸二乙酯与溴代丙酮在碱催化,再水解脱羧,然后分子内环合.

回复人：yuying2005,▲ () 时间：2006-08-25 13:30:06 编辑	4楼
这个东西味道很不好

回复人：lwqw,▲ () 时间：2007-11-06 20:59:57 编辑	5楼
我的2-甲基-1,3-环戊二酮,2-乙基-1,3-环戊二酮,就是用丙酰氯或丁酰氯和丁二酸在三氯化铝催化,二氯乙烷溶剂中环合

回复人：david_zhan,★★ () 时间：2007-11-07 21:14:51 编辑	6楼
可以通过间苯二酚加压加氢制备，是除草剂甲基磺草酮的原料。

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