问题：关于羟脯氨酸
类型：求助 (悬赏分:3分)
提问：haoqiong
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版块：有机化学问题(jimuwei,fpcwin1211,netpanda,yjgzfl,Ftian,)
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回复：7
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时间：2005-04-12 14:02:01 编辑加入/取消收藏订制/取消短消息举报该贴

谁知道他的性质啊,特别是溶于什么物质

回复人：myq1999,▲ (希望能多交几个有机合成的朋友.) 时间：2005-04-12 19:42:47 编辑

1楼

Monograph Number: 4866
Title: Hydroxyproline
CAS Registry Number: 51-35-4
CAS Name: (4R)-4-Hydroxy-L-proline
Additional Names: Hyp; Ls-hydroxyproline; (-)-(2S,4R)-4-hydroxyproline; trans-4-hydroxyproline; 4(R)-hydroxy-2(S)-pyrrolidinecarboxylic acid
Molecular Formula: C5H9NO3
Molecular Weight: 131.13.
Percent Composition: C 45.80%, H 6.92%, N 10.68%, O 36.60%
Literature References: Amino acid analog of proline, q.v.; non-essential for human development. Shows cis-trans isomerism. Constituent of collagen, q.v. Isoln from gelatin: E. Fischer, Ber. 35, 2660 (1902). Synthesis: H. Leuchs, Ber. 38, 1937 (1905); and structure determn: H. Leuchs, J. F. Brewster, Ber. 46, 986 (1913). Stereochemistry: Hudson, Neuberger, J. Org. Chem. 15, 24 (1950). Early chemistry and biochemistry: Amino Acids and Proteins, D. M. Greenberg, Ed. (Charles C. Thomas, Springfield, IL, 1951) 950 pp., passim; J. P. Greenstein, M. Winitz, Chemistry of the Amino Acids vols 1-3 (John Wiley and Sons, Inc., New York, 1961) pp. 2018-2042, passim. Flow sheets of four different syntheses: Chem. & Eng. News 40, 40 (Nov. 12, 1962). One pot synthesis: S. G. Ramaswamy, E. Adams, J. Org. Chem. 42, 3440 (1977). Proof of occurence in plants: D. Ashford, A. Neuberger, Trends Biochem. Sci. 5, 245 (1980). Effects of cis-trans isomerism on protein structure: N. Panasik, Jr. et al., Int. J. Pept. Protein Res. 44, 262 (1994). Review: R. Kuttan, A. N. Radhakrishnan, Adv. Enzymol. 37, 273-348 (1973). Review of metabolism: E. Adams, L. Frank, Ann. Rev. Biochem. 49, 1005-1061 (1980).
Properties: Rhombs or needles from water, mp 274? [a]D -76.5?(c = 2.5 in water). pK1?1.82; pK2?9.65. Soly in water at 0? 288.6 g/l; at 25? 361.1 g/l; at 50? 451.8 g/l; at 65? 516.7 g/l. Very slightly sol in alcohol. Insol in ether.
Melting point: mp 274?
pKa: pK1?1.82; pK2?9.65
Optical Rotation: [a]D -76.5?(c = 2.5 in water)

Derivative Type: cis-Form
CAS Registry Number: 618-27-9
Additional Names: Allohydroxyproline; (2S,4S)-4-hydroxyproline
Properties: mp 238-241? [a]D18 -58.1?(c = 5.2 in water).
Melting point: mp 238-241?
Optical Rotation: [a]D18 -58.1?(c = 5.2 in water)

回复人：haoqiong,▲ (有机化学博士) 时间：2005-04-13 07:18:49 编辑	2楼
晕啊,我要中文

回复人：wuwei,▲▲ () 时间：2005-04-13 17:21:46 编辑	3楼
熔点：274摄氏度，旋光值：－76.5度（C＝2.5 水）PK1＝1.82；Pk2＝9.65；在水中的溶解度：0度：288.6g/升，25度：361.1g/升；50度：451.8g/L；65度：516.7g/L；微溶于乙醇这是来至1楼

回复人：haoqiong,▲ (有机化学博士) 时间：2005-04-15 07:26:04 编辑	4楼
如果我羟脯氨酸和棕榈酰氯反应应该选什么溶剂啊

回复人：myq1999,▲ (希望能多交几个有机合成的朋友.) 时间：2005-04-15 18:59:29 编辑	5楼
试试用DMF作溶剂，以吡啶作碱，低温下滴加棕榈酰氯反应。

回复人：haoqiong,▲ (有机化学博士) 时间：2005-09-08 11:57:02 编辑	6楼
接受答案了。

回复人：yanzi322,▲ (喜欢化学) 时间：2005-09-08 12:30:08 编辑	7楼
你打算做什么产品 [该帖子已被yanzi322在2005-12-8 11:23:46编辑过]

得分人：myq1999-1,

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