问题：二环己（基）脲的性质怎样？请帮忙？
类型：求助 (悬赏分:3分)
提问：biotong
等级：▲
版块：药物化学(jaywoo,合成小象,)
信誉：100%
回复：8
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时间：2006-10-28 17:30:02 编辑加入/取消收藏订制/取消短消息举报该贴

N,N'-Dicyclohexylurea，即DCU的性质如何，特别是溶解性如何？我查资料都没查到这些，请接触过的同仁指点！！谢谢。

回复人：peptideSAR,▲ (没有权威，实验是检验学说的唯一标准！) 时间：2006-10-30 13:05:25 编辑	1楼
在常见的溶剂中都溶的不好，DMF还能溶，甲醇都很差，请教楼主用DCU做什么呀？

回复人：hunef,▲ (作合成) 时间：2006-11-01 09:51:35 编辑	2楼
DMF加热的话还溶点,冷的话很难溶解!本来就是不好溶才用DMF作溶剂,在脱水反应中从DCC来得啊

回复人：zhyf,▲ () 时间：2006-11-01 13:57:57 编辑	3楼
DCU比较特殊，它的溶解度在一般有机溶剂中都比较小，如乙酸乙酯，丙酮，氯仿，二氯甲烷。 DCU虽然在一般的有机溶剂里溶解性不太好，但一般都能溶解一部分。 DCU在室温不同溶剂中的的溶解性，DMSO、DMF 〉DCM 〉丙酮、乙酸乙酯〉乙醚。

回复人：宇轩花园,▲ (胖子) 时间：2006-11-03 12:39:28 编辑	4楼
DCC缩合得到的副产物，在各种溶剂中都能少量溶解，水不容，需要反复才能除去。要加热溶解的。

回复人：huyanhong,▲ () 时间：2006-11-09 22:43:07 编辑	5楼
我将羧酸溶在水中，DCCI会跟水反应吗？它跟羧酸还反应吗？

回复人：lxp,▲ () 时间：2006-11-14 13:39:41 编辑	6楼
DCC在DMSO、吡啶中的溶解度要大一点，我用过，你可以试试。

回复人：csali3911,▲▲ (没有描述就是好描述!) 时间：2006-11-14 22:01:25 编辑

7楼

N,N'-Dicyclohexylurea
1,3-Dicyclohexylurea
Dicyclohexylcarbodiamide

Formula C13H24N2O
Structure
Description White powder.

Registry Numbers and Inventories.
CAS 2387-23-7
EC (EINECS/ELINCS) 219-213-7
Beilstein/Gmelin 517586
Beilstein Reference 4-12-00-00052
Canada DSL/NDSL NDSL
US TSCA Listed
Japan ENCS (MITI) Listed
Korea ECL Listed

Properties.
Formula C13H24N2O
Formula mass 224.35
Melting point, °C 245
Boiling point, °C 391
Density 1.148 g/cm3
Solubility in water Insoluble
pKa/pKb 13.89 (pKa)
Partition coefficient, pKow 2.28

Hazards and Protection.
Storage Store in a cool, dry place. Store in a tightly closed container.
Handling Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Protection Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks Vacuum or sweep up material and place into a suitable disposal container.
Stability No data.
Incompatibilities Strong oxidizing agents
Decomposition Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Health.
Exposure effects The toxological properties of this substance have not been fully investigated.
Ingestion The toxicological properties of this substance have not been fully investigated.
Inhalation May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Skin May cause skin irritation.
Eyes May cause eye irritation.

First aid
Ingestion Get medical aid. Wash mouth out with water.
Inhalation Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Eyes Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

回复人：biotong,▲ (乐在其中) 时间：2008-10-30 18:10:56 编辑	8楼
已经打分了！

得分人：zhyf :1, csali3911 :2,

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