问题：DCC纯化方法
类型：求助 (悬赏分:3分)
提问：guestship
等级：▲
版块：有机化学问题(jimuwei,fpcwin1211,netpanda,yjgzfl,Ftian,)
信誉：0%
回复：2
阅读：1020
时间：2007-06-27 21:20:25 编辑加入/取消收藏订制/取消短消息举报该贴

实验室的DCC时间有点长了，而且部分已经结成小块。
请教各位高手，如何纯化DCC？
先谢谢了！

回复人：zhujieming,▲▲▲▲▲ (sioc) 时间：2007-06-27 21:30:58 编辑

1楼

1,3-Dicyclohexylcarbodimide (DCC) [538-75-0] M 206.3, m 34-35°, b 95-97°/0.2mm, 120-
121°/0.6mm, 155°/llmm. It is sampled as a liquid after melting in warm H2O. It is sensitive to air and
/'/ is a potent skin irritant. It can be distd in a vacuum and stored in a tightly stoppered flask in a freezer. It
is very soluble in CH2Cl2 and pyridine where the reaction product with H2O, after condensation, is dicyclohexyl
urea which is insoluble and can be removed by filtration. Alternatively dissolve in CH2Cl2 add powdered anhyd
MgSO4 shake 4h, filter, evaporate and distil at 0.6 mm press and oil bath temperature 145°. [Biochem Prep
10, 122 7963; Justus Liebigs Ann Chem 571 83 7957; Justus Liebigs Ann Chem 612 11 7955.]

回复人：biozhang,▲ (biochemistry) 时间：2007-06-28 16:09:46 编辑	2楼
蒸馏一下就行了

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