问题：有没有人知道以下产品的相关资料
类型：求助 (悬赏分:3分)
提问：xiaoyaolcl
等级：★★★★★
版块：有机化学问题(jimuwei,fpcwin1211,netpanda,yjgzfl,Ftian,)
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回复：6
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时间：2007-09-04 09:40:01 编辑加入/取消收藏订制/取消短消息举报该贴

英文名 ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate
别名 Carbonic acid 4-nitrophenyl 5-thiazolylmethyl ester
产品名称 ((5-噻唑基)甲基)-(4-硝基苯基)碳酸酯

回复人：silentzys,★ (专业从事工业清洗剂,水处理剂的研究) 时间：2007-09-04 09:49:23 编辑	1楼
英文名 ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate 别名 Carbonic acid 4-nitrophenyl 5-thiazolylmethyl ester 产品名称 ((5-噻唑基)甲基)-(4-硝基苯基)碳酸酯分子结构分子式 C11H8N2O5S 分子量 280.26 CAS 登录号 144163-97-3 (154212-59-6) (154212-59-6) 物理化学性质密度 1.485

回复人：silentzys,★ (专业从事工业清洗剂,水处理剂的研究) 时间：2007-09-04 09:51:45 编辑	2楼
产品名称 ((5-噻唑基)甲基)-(4-硝基苯基)碳酸酯中国供应商浙江华海药业股份有限公司厦门市先邦生物化学有限公司

回复人：afc,★★ (氟化学产品) 时间：2007-09-04 09:58:12 编辑

3楼

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate

A solution comprising 21.0 Kg. (104 mole) 4-nitrophenyl chloroformate dissolved into 75 L ethyl acetate was prepared. The solution was cooled to -5° C. and 0.4 Kg (4 mole) of pyridine dissolved, into 18 L ethyl acetate, was added. The resulting slurry was stirred at -5°±5° C. After 1 hour, 5-hydroxymethyl thiazole 10.0 Kg (87 mole), (HMT) dissolved into 75 L ethyl acetate, was added over 30-40 minutes, maintaining the reaction mixture temperature at -5°±3° C. The resulting slurry was then warmed to 0°±5° C., and stirred for at least about 24 hours. The reaction was checked for completion by HPLC. Upon completion, absolute ethanol, 32 Kg, was added to the slurry (about 15-20% of the total reaction volume), stirred for at least about 2 hours, and then centrifuged or filtered. The product solid was washed with cold ethyl acetate (2×75 L) and dried at 40°±5° C. to an LOD <2%. Yield: 25.15 Kg (93%).

Results are illustrated below.

1 H NMR (CDCl3) d 5.53 (s, 2H), 7.39 (dt, J =9, 3 Hz, 2H), 8.01 (s, 1H), 8.29 (dt, J =9, 3 Hz, 2H), 8.90 (s, 1H). Mass spectrum: (M+H)+ =281.

回复人：afc,★★ (氟化学产品) 时间：2007-09-04 10:06:44 编辑

4楼

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate.

A solution of 3.11 g (27 mmol) of 5-(hydroxymethyl)thiazole and excess N-methyl morpholine in 100 ml of methylene chloride was cooled to 0.degree. C. and treated with 8.2 g (41 mmol) of 4-nitrophenyl chloroformate. After being stirred for 1 h, the reaction mixture was diluted with CHCl.sub.3, washed successively with 1N HCl, saturated aqueous NaHCO.sub.3, and saturated brine, dried over NaSO.sub.4, and concentrated in vacuo. The residue was purified by silica gel chromatography (SiO2, 1-2% MeOH/CHCl.sub.3, Rf=0.5 in 4% MeOH/CHCl.sub.3) to yield 5.9 g (78%) of the desired compound as a yellow solid. NMR (CDCl.sub.3) .delta.5.53 (s, 2H), 7.39 (dt, J=9, 3 Hz, 2H), 8.01 (s, 1H), 8.29 (dt, J=9, 3 Hz, 2H), 8.90 (s, 1H). Mass spectrum: (M+H).sup.+ =281.

回复人：xiaoyaolcl,★★★★★ (由于爱好,所以从事) 时间：2007-09-04 10:46:57 编辑	5楼
已经打分了！

回复人：jxshdh,▲ () 时间：2007-09-22 15:24:17 编辑	6楼
那个有工业化学书啊发到24769550011@qq.com

得分人：afc:3,

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