问题：各位大侠帮帮忙，焦急请教uranyl nitrate（硝酸双氧铀）对人的危害
类型：求助 (悬赏分:3分)
提问：muys
等级：▲
版块：无机化学(mitang,lmybenny,wanghong,llscmary,abingchem,)
信誉：100%
回复：2
阅读：641
时间：2007-12-01 02:20:07 编辑加入/取消收藏订制/取消短消息举报该贴

近来我朋友要用uranyl nitrate做实验，要研究六价铀还原为三价铀的反应动力学机制，具体情况如下：

采用的uranyl nitrate标准溶液浓度为(997mg/L),然后用这个在一般的通风橱来配储备溶液（配储备溶液含量可能高达376.0umol/L），实验采用铁作还原剂，在加上一些pH缓冲溶液等。整个实验是在一个塑料的无氧室里面进行，这个anoxic gas chamber设计有塑料手套来操作实验。人不直接接触溶液，但作实验时只穿白大褂，好像没有特别的防护服，也没看见带口罩。整个实验（包括预实验和正式实验）估计要2-3个月，实验时也不是一直待在实验室，而是按照一定的时间间隔（估计每隔几个小时或一天）去实验室取样，反应结束后，会将铀的还原产物过滤出来去做透射电子显微镜来研究产物的形态和成分。

但不清楚uranyl nitrate的放射性有多大？在这样的条件下做实验对人的伤害有多大？会得些什么病并影响人的生育能力吗？如果非做不可，要采取怎样的防护措施？要穿什么样的防护服？
急求各位高人指点！！先谢各位了！

回复人：afc,★★ (氟化学产品) 时间：2007-12-01 07:59:45 编辑

1楼

Physical Constants of Uranyl Nitrate Hexa Hydrate

CAS #
Formula
Formula Weight

Color Crystalline Form
Specific Gravity Melting Point
Boiling Point

Solubility in 100 parts

Cold Water
Hot Water
Other Reagents

INTERNATIONAL BIO-ANALYTICAL INDUSTRIES, INC.
MATERIAL SAFETY DATA SHEET
Date Printed: 12/14/2003
Date Updated: 09/02/2002
Version 1.1
--------------------------------------------------------------
Section 1 - Product and Company Information
--------------------------------------------------------------
Product Name URANYL NITRATE HEXAHYDRATE, ACS
Product Number 42046
Brand IBI
Company International Bio-Analytical Industries, Inc.
Street Address 3595 North Dixie Hwy. Unit # 5
City, State, Zip, Country Boca Raton, Florida 33431 USA
Technical Phone: 561-826-0061
Emergency Phone: CHEMTREC 800-424-9300
Fax: 561-892-8450
--------------------------------------------------------------
Section 2 - Composition/Information on Ingredient
--------------------------------------------------------------
Substance Name CAS # SARA 313
URANYL NITRATE 13520-83-7 No
Formula N2O8U·6H2O
Chemical Family Radioactive material.
Synonyms Dinitratodioxouranium hexahydrate * Uranium,
bis(nitrato-O)dioxo-, hexahydrate (T-4)- (9CI) *
Uranium, dinitratodioxo-, hexahydrate * Uranyl
dinitrate hexahydrate * Uranylnitrate hexahydrate
RTECS Number: YR3850000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Oxidizing. Highly Toxic (USA) Very Toxic (EU).
Contact with combustible material may cause fire. Very toxic if swallowed. Irritating to respiratory system and skin. Limited evidence of a carcinogenic effect. Risk of serious damage to eyes.
Calif. Prop. 65 carcinogen. Target organ(s): Kidneys. Liver.
For additional information on toxicity, please refer to Section 11.
--------------------------------------------------------------
Section 4 - First Aid Measures
--------------------------------------------------------------
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
--------------------------------------------------------------
Section 5 - Fire Fighting Measures
--------------------------------------------------------------
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Contact with other material may cause fire.
Emits toxic fumes under fire conditions.
--------------------------------------------------------------
Section 6 - Accidental Release Measures
--------------------------------------------------------------
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Handle as a radioactive spill.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material pickup is complete.
--------------------------------------------------------------
Section 7 - Handling and Storage
--------------------------------------------------------------
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Store in a cool dry place.
--------------------------------------------------------------
Section 8 - Exposure Controls / PPE
--------------------------------------------------------------
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Other: Wear appropriate government approved respirator,
chemical-resistant gloves, safety goggles, other protective
clothing.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
IBI - 94270
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA MSHA Standard-air TWA 0.2 MG(U)/M3
USA OSHA. PEL 8H TWA 0.05 MG(U)/M3
--------------------------------------------------------------
Section 9 - Physical/Chemical Properties
--------------------------------------------------------------
Appearance Form: Crystals
Property Value At Temperature or Pressure
Molecular Weight 502.1 AMU
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
--------------------------------------------------------------
Section 10 - Stability and Reactivity
--------------------------------------------------------------
STABILITY
Stable: Stable.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Nitrogen oxides, Uranium oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur.
--------------------------------------------------------------
Section 11 - Toxicological Information
--------------------------------------------------------------
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe eye irritation.
Inhalation: Material is irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.
Ingestion: May be fatal if swallowed.
IBI - 94270
TARGET ORGAN(S) OR SYSTEM(S)
Kidneys. Liver. Lungs. Brain. Damage to the kidneys. Damage to
the liver. Damage to the lungs.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
Exposure can cause: Damage to the kidneys. Damage to the liver.
Damage to the lungs. Blood effects. Symptoms may be delayed.
TOXICITY DATA
Intraperitoneal
Rat
135 MG/KG
LD50
Subcutaneous
Chicken
299 MG/KG
LD50
Remarks: Lungs, Thorax, or Respiration:Structural or functional change in trachea or bronchi. Liver:Other changes. Kidney, Ureter, Bladder:Other changes.
CHRONIC EXPOSURE - CARCINOGEN
Result: Contains a radioactive isotope which may produce cancer and genetic mutation.
CHRONIC EXPOSURE - MUTAGEN
Species: Hamster
Dose: 180 MG/L
Cell Type: lung
Mutation test: Cytogenetic analysis
--------------------------------------------------------------
Section 12 - Ecological Information
--------------------------------------------------------------
No data available.
--------------------------------------------------------------
Section 13 - Disposal Considerations
--------------------------------------------------------------
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Dispose of spilled material as radioactive waste. Consult local, state, and federal regulations on the disposal of radioactive waste. Observe all federal, state, and local environmental regulations.
--------------------------------------------------------------
Section 14 - Transport Information
--------------------------------------------------------------
IATA
Proper Shipping Name: Nitrates, inorganic, n.o.s.
IATA UN Number: 1477
Hazard Class: 5.1
Packing Group: II
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: T+ R N
Indication of Danger: Very toxic. Radioactive. Dangerous for the environment.
IBI - 94270
R: 26/28 33 51/53
Risk Statements: Very toxic by inhalation and if swallowed.
Danger of cumulative effects. Toxic to aquatic organisms, may
cause long-term adverse effects in the aquatic environment.
S: 20/21 45 61
Safety Statements: When using do not eat, drink, or smoke. In
case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). Avoid release to
the environment. Refer to special instructions/safety data
sheets.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Oxidizing. Highly Toxic (USA) Very Toxic
(EU).
Risk Statements: Contact with combustible material may cause
fire. Very toxic if swallowed. Irritating to respiratory system and skin. Limited evidence of a carcinogenic effect. Risk of serious damage to eyes.
Safety Statements: Keep away from combustible material. Do not
breathe dust. Wear suitable protective clothing, gloves, and
eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
US Statements: Calif. Prop. 65 carcinogen. Target organ(s):
Kidneys. Liver.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: California Proposition 65: This product is or contains chemical(s) known to the state of California to
cause cancer. California Proposition 65: This product is or
contains chemical(s) known to the state of California to cause
cancer.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: No
NDSL: No
--------------------------------------------------------------
Section 16 - Other Information
--------------------------------------------------------------
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide.
IBI., shall not be held liable for any damage
resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms and conditions of sale. License
granted to make unlimited paper copies for internal use only.
IBI - 94270

回复人：muys,▲ (从事环境化学方面的研究) 时间：2007-12-01 13:43:04 编辑

2楼

非常感谢1楼的答复！那要是像上面所说的条件做这种实验岂不是很危险。另外Uranyl Nitrate Hexa Hydrate和uranyl nitrate是同一种试剂吗？uranyl nitrate的性质和毒性又怎样？要是有uranyl nitrate的类似信息，也麻烦告诉一下。此外uranyl nitrate的放射性到什么程度？其中铀的同位素组成咋样？放射性的同位素比如U235含量有多少？现在急等着做最终的决定，盼各位大侠伸出援手。谢谢！

[该帖子已被muys在2007-12-01 13:51:17编辑过]

得分人：afc :2,

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