问题：跪求2-溴吡啶的合成及相关信息
类型：求助 (悬赏分:3分)
提问：无痕008
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版块：有机化学问题(jimuwei,fpcwin1211,netpanda,yjgzfl,Ftian,)
信誉：100%
回复：6
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时间：2008-05-14 19:13:02 编辑加入/取消收藏订制/取消短消息举报该贴

毕业论文要做2-溴吡啶的合成，关于他的应用和市场前景的信息一点没有，很着急，有他的最佳合成条件最好，非常感谢！！！！

回复人：afc,★★ (氟化学产品) 时间：2008-05-18 10:56:45 编辑

1楼

In a 5-l. three-necked flask fitted with a mechanical stirrer , a dropping funnel, and a thermometer for reading low temperatures is placed 790 ml. (7 moles) of 48% hydrobromic acid. The
flask and contents are cooled to 10–20° in an ice-salt bath, and 150 g. (1.59 moles) of 2-aminopyridine is added over a period of about 10 minutes. While the temperature is kept at 0° or lower, 240ml. (4.7 moles) of bromine is added dropwise . A solution of 275 g. (4 moles) of sodium nitrite in 400 ml. of water is added dropwise over a period of 2 hours, the temperature being carefully maintained at 0° or lower . After an additional 30 minutes of stirring, a solution of 600 g. (15moles) of sodium hydroxide in 600 ml. of water is added at such a rate that the temperature does not rise above 20–25° (Note 5). The nearly colorless reaction mixture is extracted with four 250-ml. portions of ether . The extract is dried for 1 hour over 100 g. of solid potassium hydroxide and is then distilled through a Vigreux column 15 cm. in length. 2-Bromopyridine distils at 74–75°/13 mm., and the yield is 216–230 g. (86–92%)

回复人：seaword,▲▲▲▲ (人生合成，合成人生) 时间：2008-05-14 20:07:13 编辑	2楼
可以尝试用2-氨基吡啶做

回复人：pengxiaowe,▲ (胡思乱想有机合成) 时间：2008-05-18 08:17:57 编辑	3楼
把2-氯吡啶溶解在乙酸溶剂中,加热到115-125℃,然后通入HBr气体制备2-溴吡啶.即55 g HBr气体在10 h内慢慢通入到温度为120℃的含有30.8 g 2-氯吡啶的500mL乙酸中,生成81.4％的2-溴吡啶,纯度98.6％.

回复人：pengxiaowe,▲ (胡思乱想有机合成) 时间：2008-05-18 08:20:10 编辑	4楼
2-氯吡啶可由吡啶制备资料比较多你自己查查吧

回复人：rqs1,★★★★ (技术提升为己任) 时间：2008-05-18 08:49:01 编辑	5楼
2-氨基吡啶进行重氮化再溴化，以往中试生产过！收率还可！具体工艺没有电子版的，不好给你！

回复人：xiaoyaolcl,★★★★★ (由于爱好,所以从事) 时间：2008-05-18 13:37:42 编辑	6楼
已经打分了！

得分人：pengxiaowe :1, rqs1 :1, afc :3,

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