问题：急需，请教一反应!
类型：求助 (悬赏分:3分)
提问：kangrui369
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版块：有机化学问题(jimuwei,fpcwin1211,netpanda,yjgzfl,Ftian,)
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回复：2
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时间：2008-05-24 10:36:12 编辑加入/取消收藏订制/取消短消息举报该贴

哪位知道用丙二腈和甲酸甲酯（或乙酯）如何制备乙氧基亚甲基丙二腈？

[该帖子已被kangrui369在2008-05-24 10:39:42编辑过]

回复人：afc,★★ (氟化学产品) 时间：2008-05-24 11:06:52 编辑

1楼

下面是用丙二腈和原甲酸三乙酯合成的，共参考！
malononitrile3．3g(50．Ommo1)，ethyl orthoformate 11．1g (75．0
mmo1)and acetic anhydride 12．8g(125．5
mmo1)were mixed in a three neeked flask with
stirring．The mixture was refluxed for 6h at
95℃ ．Then a little charcoalwas added． The
solvent was removed from the mixture by disti1
lation．The hot residue was filtered and the
filter cake was washed with hot ethano1．the
filtrate was placed in a refrigeretor overnight．
After filtradon， the crystalline Was washed
witl1 ice—cold ethanol and dried to get 3 5．Og，
yield 82．5%,mp:66~C～ 68

[该帖子已被afc在2008-05-24 11:09:21编辑过]

回复人：kangrui369,▲ () 时间：2008-05-24 11:35:36 编辑	2楼
丙二腈和原甲酸三乙酯合成我已经用过了，成本太高。

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