问题：急求论文摘要翻译
类型：求助 (悬赏分:3分)
提问：pandong423
等级：▲
版块：药物化学(jaywoo,合成小象,)
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回复：2
阅读：506
时间：2008-06-19 19:06:46 编辑加入/取消收藏订制/取消短消息举报该贴

头孢克肟为口服半合成第三代头孢菌素。可抑制大多数革兰氏阴性菌包括嗜血菌属，奈瑟球菌属和肠杆菌科的大多数菌种，如耐氨苄西林、甲氧苄啶、碳铵甲恶唑和头孢氨苄菌株的生长。它对肺炎链球菌和大多数－溶血性链球菌有活性。
栓剂中药物吸收的一个重要特点是部分药物经中痔静脉、下痔静脉吸收后直接进入下腔静脉，大部分药物避免了肝脏的首过效应。但一般栓剂在直肠熔化或溶解后，都会向直肠上部扩散，使相当部分药物由上痔静脉吸收经门静脉入肝。将头孢克肟制成双层栓，前部的空白层阻止了后部所释药物向上扩散，可提高利用度。
经试验用热溶法制备头孢克肟双层栓剂，工艺可行、重现性好。所得栓剂质量合格、稳定。

回复人：jianghai,★★★★★ (学到老，活到老！) 时间：2008-06-19 20:55:01 编辑

1楼

Cefixime for oral semi-synthetic third-generation cephalosporins. Can inhibit the most bloodthirsty species, including gram-negative bacteria, Neisseria and Enterobacteriaceae is the most bacteria, such as resistant to ampicillin, trimethoprim, ammonium bicarbonate A strain of the oxazolidine and cephalexin生长. Streptococcus pneumoniae, and most of it - hemolytic streptococcus active.
Suppository in drug absorption is an important characteristic of some of the drug in the hemorrhoid vein, the vein hemorrhoids absorbed directly into the vena cava, most of the drug to avoid the effects of the first liver. But the general rectal suppository in the melting or dissolved, will the rectum to the top of proliferation, so that a significant portion of the drug from hemorrhoids absorption by the portal vein Rugan. Cefixime will be made of double-bolt, the front of the stop-gap in the rear by the upward address the proliferation of drugs, can increase the use of.
The test used Rerong Preparation cefixime double-suppository, the technology is feasible and reproducible. From the suppository quality standards, and stable.

回复人：高粱米大碴子,★ () 时间：2008-06-21 04:43:25 编辑

2楼

照骡子画马，根据jianghai的翻译加了点人工！

头孢克肟为口服半合成第三代头孢菌素。
Cefixime for in an oral semi-synthetic third-generation cephalosporins

可抑制大多数革兰氏阴性菌包括嗜血菌属，奈瑟球菌属和肠杆菌科的大多数菌种，如耐氨苄西林、甲氧苄啶、碳铵甲恶唑和头孢氨苄菌株的生长。
It can inhibit most of gram-negative bacteria including bloodthirsty species, and most of Neisseria and Enterobacteriaceae, such as resistant to ampicillin, trimethoprim, ammonium bicarbonate A strain of the oxazolidine and cephalexin.

它对肺炎链球菌和大多数－溶血性链球菌有活性。
It has activity towards Streptococcus pneumoniae, and most of hemolytic streptococcus.

栓剂中药物吸收的一个重要特点是部分药物经中痔静脉、下痔静脉吸收后直接进入下腔静脉，大部分药物避免了肝脏的首过效应。
One of the important characteristic in Suppository is that the drug absorbed through the hemorrhoid vein, directly into the vena cava, avoid the “first-liver-through”(这个不知如何翻译了) effects.

但一般栓剂在直肠熔化或溶解后，都会向直肠上部扩散，使相当部分药物由上痔静脉吸收经门静脉入肝。
But common suppositories proliferate through the up rectum during the process of melting and/or dissolving, a significant portion of the drug absorbed from hemorrhoids, via the portal vein to the liver.

将头孢克肟制成双层栓，前部的空白层阻止了后部所释药物向上扩散，可提高利用度。
Cefixime is made double-bolted, the top gap in the bolt limited upward proliferation of the drug, and the efficiency of the usage is also increased.

经试验用热溶法制备头孢克肟双层栓剂，工艺可行、重现性好。所得栓剂质量合格、稳定。

The experiment has showed that the technology of hot-melt method to make double-suppository is feasible and reproducible. The suppository made using this technology meets the standards, with good stability.

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