问题：请教溴化问题！
类型：求助 (悬赏分:3分)
提问：zhulimin
等级：▲
版块：有机化学问题(jimuwei,fpcwin1211,netpanda,yjgzfl,Ftian,)
信誉：92%
回复：4
阅读：619
时间：2008-08-04 23:22:53 编辑加入/取消收藏订制/取消短消息举报该贴

我想用溴素做溴化试剂，底物为对硝基氯苯，用铁粉做催化剂！不知道能不能生成3-溴-4-氯硝基苯？？？不知道哪位高人有这方面的参考资料吗？麻烦发给我一下！我的邮箱：zhulimin_10213@163.com

回复人：晓亮20030078,▲ (我材料的) 时间：2008-08-05 10:49:37 编辑

1楼

Entry Name: 1-Chloro-4-nitrobenzene
Synonym(s): p-Chloronitrobenzene
Chapman Hall Number: DWX19-Z
CAS Registry Number: 100-00-5
Extra CAS Registry Numbers(s): 25167-93-5
Structure by analogy with 1-Chloro-2-nitrobenzene, DWX17-X

Molecular Formula: C6H4ClNO2
Molecular Weight: 157.556
Accurate Mass: 156.993056
Percentage Composition: C 45.74%; H 2.56%; Cl 22.50%; N 8.89%; O 20.31%
Physical Description: Cryst.
Melting Point: Mp 83
Boiling Point: Bp 242. Bp8 113
Dissociation Constant: pKa 11.56 (18, H2SO4 aq.)
Hazard Toxicity: Fl. p. 126-127. OES: long-term 1 mg m3; short-term 2 mg m3 (Sk). Can react violently with NaOMe. Occup. exposure caused development of methaemoglobinaemia, and anaemia (mild). Exp. haematological and hepatic effects
RTECS Accession Number: CZ1050000

Aldrich: C5912-2
Fluka:
References:
Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 695A, (nmr)
Aldrich Library of FT-IR Spectra, 1st edn., 1985, 1, 1340A, (ir)
Aldrich Library of FT-IR Spectra: Vapor Phase, 1989, 3, 1191C, (ir)
Aldrich Library of NMR Spectra, 5, 154A, (pmr)
Hodgson, H.H. et al., J.C.S., 1944, 22; 1945, 545; 819, (synth)
Newman, M.S. et al., J.A.C.S., 1947, 69, 1221, (synth)
Beistel, D.W. et al., J. Phys. Chem., 1976, 80, 2023, (cmr)
Uemura, S. et al., J.C.S. Perkin 1, 1978, 1076, (synth)
Sastry, S. et al., Indian J. Chem., Sect. B, 1979, 18, 198, (synth)
Zuccarello, F. et al., Spectrochim. Acta A, 1979, 35, 223, (uv)
Harrison, A.G. et al., Org. Mass Spectrom., 1980, 15, 286, (ms)
Rao, G.R. et al., J. Raman Spectrosc., 1989, 20, 529, (ir, Raman)
Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, NFS525
Bretherick, L., Handbook of Reactive Chemical Hazards, 4th edn., Butterworths, 1990, 2011
Luxon, S.G., Hazards in the Chemical Laboratory, 5th edn., Royal Society of Chemistry, 1992, 313

回复人：ye,▲▲ (做有机合成研发的) 时间：2008-08-05 14:13:33 编辑	2楼
用无水三溴化铁做催化剂，不要加容剂，在80摄氏度（或更高），滴加滴加溴素试

回复人：飘逸雪,★ (将天然有机产物的合成做为艺术的一个合成人) 时间：2008-08-05 19:16:32 编辑	3楼
这个应该很容易的了上Beisteil上查一下就可以了

回复人：zhulimin,▲ (加油，哥们~！) 时间：2008-08-05 23:27:48 编辑	4楼
已经打分了！

得分人：ye :1,

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