问题：氰基制备酮
类型：求助 (悬赏分:3分)
提问：rms
等级：▲
版块：有机化学问题(jimuwei,fpcwin1211,netpanda,yjgzfl,Ftian,)
信誉：96%
回复：5
阅读：425
时间：2009-02-26 10:35:42 编辑加入/取消收藏订制/取消短消息举报该贴

请教各位高手
苯甲腈与烯丙基溴能制备得到相应的酮吗？
能介绍相关的文献吗？小弟查了很久都没有到

回复人：rms,▲ () 时间：2009-02-26 16:00:04 编辑	1楼
已经打分了！

回复人：rms,▲ () 时间：2009-02-26 16:00:05 编辑	2楼
已经打分了！

回复人：claymore,★★★★★ (C-H活化，kumada,suzuki,stille,negishi.cross-coupling.) 时间：2009-02-26 11:32:41 编辑	3楼
可以

回复人：claymore,★★★★★ (C-H活化，kumada,suzuki,stille,negishi.cross-coupling.) 时间：2009-02-26 11:47:49 编辑	4楼
巴比耶类型的反应，用ZN/ALCL3路易斯酸催化。

回复人：claymore,★★★★★ (C-H活化，kumada,suzuki,stille,negishi.cross-coupling.) 时间：2009-02-26 11:51:50 编辑

5楼

aluminum trichloride (0.4mmol) was added at once to a solution of zinc powder (4.0 mmol), nitrile (1.0 mmol) and allylic bromide (1.5 mmol) in anhydrous THF (5 mL) at 0°C (ice-water bath).22 The reaction mixture was warmed to room temperature and then stirred at room temperature. After the reaction was completed (monitored by TLC), aqueous HCl (2 M, 5 mL) was added to the reaction mixture
and stirred at room temperature for 5 minutes. The reaction mixture was passed through a shortsilica gel column and the organic solvent was removed directly under reduced pressure. Further purification is achieved on a flash chromatograph with ethyl acetate:hexane as eluant.

得分人：claymore :1,

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