问题：求助合成方法文献
类型：求助 (悬赏分:3分)
提问：guofeng
等级：▲
版块：网友资源互助区(Yan,)
信誉：100%
回复：7
阅读：1679
时间：2005-06-13 09:52:49 编辑加入/取消收藏订制/取消短消息举报该贴

化学合成方法文献
2-(4-chlorobenzyl)-1H-benzimidazole
CAS#: [5468-66-6]
年代不限,多多益善
谢谢!
email:gnefoug@21cn.com

回复人：zhixiangch,▲▲▲▲ (希望来这里和大家交朋友，相互交流和学习知识。) 时间：2005-06-13 10:16:32 编辑	1楼
将贝尔斯坦查询结果已发送到你的邮箱。

回复人：guofeng,▲ () 时间：2005-06-14 11:31:02 编辑	2楼
感谢zhixiangch 请加分.

回复人：wguoyong,▲▲▲▲ (原来做药物化学的，现在从事表面活性剂/洗涤剂研究开发) 时间：2005-06-15 22:19:03 编辑

3楼

Substance Identifier task started on Wed Jun 15, 2005 at 10:14 PM

Explored by Substance Identifier in REGISTRY.

REGISTRY Answers
1 for 5468-66-6

Get References started for 5468-66-6

4 "Preparation" references were found for 5468-66-6 in CAPLUS and MEDLINE

Copyrights:

CAPLUS: Copyright 2005 ACS (The UK patent material in this product/service is UK Crown copyright and is made available with permission. (C) Crown Copyright. The French (FR) patent material in this product/service is made available from Institut National de la Propriete Industrielle (INPI).)
MEDLINE: Produced by the U.S. National Library of Medicine
REGISTRY: Copyright 2005 ACS (Some records contain information from GenBank(R). See also: Benson D.A., Karsch-Mizrachi I., Lipman D.J., Ostell J., Rapp B.A., Wheeler D.L. Genbank. Nucl. Acids Res. 28(1):15-18 (2000). Property values tagged with IC are from the ZIC/VINITI data file provided by InfoChem.)
CASREACT: Copyright 2005 ACS (In addition to reactions indexed by CAS, CASREACT contains reactions derived from the following sources: ZIC/VINITI database (1974-1991) provided by InfoChem, INPI data prior to 1986, and Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich.)
CHEMLIST, CHEMCATS: Copyright 2005 ACS

Bibliographic Information

Proximity effects in the electron impact mass spectra of 2-substituted benzazoles. Chantler, Thomas; Perrin, Victoria L.; Donkor, Rachel E.; Cawthorne, Richard S.; Bowen, Richard D. Chemical and Forensic Sciences, University of Bradford, Bradford, UK. International Journal of Mass Spectrometry (2004), 236(1-3), 65-80. CODEN: IMSPF8 ISSN: 1387-3806. Journal written in English. CAN 141:379571 AN 2004:687835 CAPLUS (Copyright 2005 ACS on SciFinder (R))

Abstract

The 70 eV electron impact mass spectra of a wide range of 2-substituted benzazoles are reported and discussed. Particular attention is paid to the mechanistic significance and anal. utility of [M-H]+ and [M-X]+ signals in the spectra of benzazoles in which the 2-substituent contains a terminal aryl group with one or more substituents, X. Loss of H.bul. or X.bul. occurs preferentially from an ortho-position from ionized 2-benzylbenzimidazoles, 2-phenethylbenzimidazoles, 2-styrylbenzimidazoles, 2-styrylbenzoxazoles and 2-styrylbenzothiazoles. In the three styrylbenzazole series, the [M-H]+ and/or [M-X]+ signals dominate the spectra. This unusually facile loss of H.bul. or X.bul. may be attributed to a proximity effect, in which cyclization of the ionized mol. is followed by elimination of an ortho-substituent to give an exceptionally stable polycyclic ion. Formation of a new five- or six-membered ring by the proximity effect occurs rapidly; cyclization to a seven-membered ring takes place rather less readily; but formation of a ring with only four atoms or more than seven atoms is not obsd. to a significant extent. The proximity effect competes effectively with loss of a Me radical by simple cleavage of an Et, iso-Pr and even a t-Bu group in the pendant arom. ring of ionized 2-(4-alkylstyryl)benzazoles.

Bibliographic Information

Synthesis, characterization and mutagenicity of new cis-[Pt(2-substituted-benzimidazole)2Cl2] complexes. Guemues, F.; Demirci, A. B.; Oezden, T.; Eroglu, H.; Diril, N. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Turk. Pharmazie (2003), 58(5), 303-307. CODEN: PHARAT ISSN: 0031-7144. Journal written in English. CAN 140:207 AN 2003:394310 CAPLUS (Copyright 2005 ACS on SciFinder (R))

Abstract

In this study, four new platinum(II) complexes with the structures cis[Pt(Ligand)2Cl2] (ligand = 2-(p-methoxy-/or-p-chlorobenzyl or p-methoxyphenyl)benzimidazol) and 5(6)-methyl-2-phenoxymethylbenzimidazole were synthesized and characterized by their elemental anal., and IR and 1H NMR spectra. The potentials of the Pt(II) complexes for short-term bacterial mutagenicity were tested in reverse-mutation assays using Salmonella typhimurium frame-shift strain T 98 and S. typhimurium TA 100 and TA 102 strains, which carry mutations particularly sensitive to reversion by DNA base-pair substitution. The tests were performed in the absence of S9 rat liver fraction. Among the complexes tested 1 had no mutagenic activity. Another complex was found to be weakly mutagenic in TA 98 only. The Pt(II) complexes were found to be mutagenic in TA 98, TA 100 and TA 102.

Bibliographic Information

Product class 4: benzimidazoles. Grimmett, M. R. Organic Chemistry, Dept. of Chemistry, University of Otago, Dunedin, N. Z. Science of Synthesis (2002), 12 529-612. CODEN: SSCYJ9 Journal; General Review written in English. CAN 139:179987 AN 2002:855869 CAPLUS (Copyright 2005 ACS on SciFinder (R))

Abstract

A review. Methods for prepg. benzimidazoles are reviewed covering annulations to arenes, ring transformations, and aromatization. Modification of benzimidazole substituents are also included.

Bibliographic Information

Synthesis of 2-substituted benzimidazoles as antiinflammatory agents. Moon, Seung Wook; Jahng, Yurngdong; Seoh, Byeong Chon. Coll. Pharm., Yeungnam Univ., Kyungsan, S. Korea. Yakhak Hoechi (1992), 36(1), 7-11. CODEN: YAHOA3 ISSN: 0513-4234. Journal written in Korean. CAN 121:230712 AN 1994:630712 CAPLUS (Copyright 2005 ACS on SciFinder (R))

Abstract

Title compds. I (R = alkyl, benzyl, substituted benzyl; R1 = H, Me) were prepd. by reacting phenylenediamines with RCOCl. I showed no significant antiinflammatory activity.

回复人：guofeng,▲ () 时间：2005-06-22 08:44:24 编辑	4楼
同样感谢! 可否也给加分

回复人：hanhuang01,▲▲▲▲ (love) 时间：2005-06-22 11:03:06 编辑	5楼
高手多多啊!

回复人：deng_jin,▲▲▲ (理论有机，研究方向：利用计算机辅助量化计算研究外部场（电磁复合场）对空间有机选择性合成) 时间：2005-06-23 13:38:34 编辑	6楼
接受答案了。

回复人：wmh109,▲▲▲ (我是一名化工行业的小学生) 时间：2005-07-07 20:41:00 编辑	7楼
GAO SHOU A

得分人：zhixiangch-2,wguoyong-2,

问题讨论没有结束...

您尚未进入本论坛,登录之后才可以回贴

9msec