问题：文献求助A potential prebiotic route to adenine from hypoxanthine.
类型：求助 (悬赏分:5分)
提问：hbleolee
等级：▲
版块：文献代查(hipbird,playdoom,claymore,)
信誉：100%
回复：2
阅读：535
时间：2011-06-21 08:57:21 编辑加入/取消收藏订制/取消短消息举报该贴

Chem Biodivers. 2005 Jul;2(7):923-7.
A potential prebiotic route to adenine from hypoxanthine.
Lagoja IM, Herdewijn P.
SourceLaboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven. irene.lagoja@rega.kuleuven.ac.be

Abstract
A possible reaction mechanism for the dehydration of glycinamide (3) and N,N'-diformylurea (4) yielding hypoxanthine (2) has been investigated. Furthermore, a potential prebiotic route converting hypoxanthine (2) into adenine (1) via phosphate activation followed by substitution reaction with NH3 was studied. This reaction mimics the proposed biochemical mechanism for the conversion of IMP to AMP.

回复人：claymore,★★★★★ (C-H活化，kumada,suzuki,stille,negishi.cross-coupling.) 时间：2011-06-21 10:00:14 编辑	1楼
附件：923_ftp.pdf (下载一次扣除可用分1分。附件提供人得到0.5分)

回复人：hbleolee,▲ () 时间：2011-06-21 10:18:39 编辑	2楼
谢谢

得分人：claymore :5,

问题讨论没有结束...

您尚未进入本论坛,登录之后才可以回贴

5msec