问题：文献求助A potential prebiotic route to adenine from hypoxanthine.
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提问：hbleolee
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Chem Biodivers. 2005 Jul;2(7):923-7.
A potential prebiotic route to adenine from hypoxanthine.
Lagoja IM, Herdewijn P.
SourceLaboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven. irene.lagoja@rega.kuleuven.ac.be

Abstract
A possible reaction mechanism for the dehydration of glycinamide (3) and N,N'-diformylurea (4) yielding hypoxanthine (2) has been investigated. Furthermore, a potential prebiotic route converting hypoxanthine (2) into adenine (1) via phosphate activation followed by substitution reaction with NH3 was studied. This reaction mimics the proposed biochemical mechanism for the conversion of IMP to AMP.

回复人：claymore,★★★★★ (C-H活化，kumada,suzuki,stille,negishi.cross-coupling.) 时间：2011-06-21 10:00:14 编辑	1楼
附件：923_ftp.pdf (下载一次扣除可用分1分。附件提供人得到0.5分)

回复人：hbleolee,▲ () 时间：2011-06-21 10:18:39 编辑	2楼
谢谢

得分人：claymore :5,

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