问题：求助合成文献
类型：求助 (悬赏分:6分)
提问：bugaode
等级：▲
版块：有机化学问题(jimuwei,fpcwin1211,netpanda,yjgzfl,Ftian,)
信誉：29%
回复：1
阅读：444
时间：2011-06-24 07:09:25 编辑加入/取消收藏订制/取消短消息举报该贴

寻求帮助：
以环丙基甲基酮(cas:765-43-5)为原料合成对氯苯基环丙基甲基酮（cas:6640-25-1）的合成文献，请给予支持！先谢了！

回复人：tangyyer,★★★★★ (有空来逛逛my blog: http://tangyyer.blog.hexun.com) 时间：2011-06-25 05:57:52 编辑

1楼

环丙基甲基酮直接进行转换应该很难吧，毕竟甲基到苯环是需要减碳的。

可以试试这个：
4-Chlorophenyl cyclopropyl ketone was prepared as follows : 4-
chlorobutyryl chloride (20 g) in chlorobenzene (20 ml) was added
over a period of 10 min at 10-15°C t o anhydrous aluminium
chloride (20 g) in chlorobenzene (100 ml), and the mixture then
stirred a t 20-25°C for 1h. Threaction product was poured
into a mixture of ice and hydrochloric acid, and then processed
(without distillation). The residue was treated with potassium
hydroxide (12 g) in methanol (60 ml) for 30 min, the mixture
filtered, and the filtrate and washings evaporated t o a residue
which was processed to give the required product (21.3 g, 84%)
b.p. 125-127"C/0.5 mmHg, ~ D Z O 1.5702,n.m.r. peaks a t 60.7-
1.3 (m, 4H, 2xCH2) 2.3-2.7 (m, 1H) cyclopropyl CH) 7.3-8.0
(m, 4H, aromatic Hs ) .

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