问题：求一化合物的合成方法或路线
类型：求助 (悬赏分:3分)
提问：ZHFENG
等级：▲
版块：文献代查(hipbird,playdoom,claymore,)
信誉：93%
回复：4
阅读：595
时间：2011-08-05 09:09:00 编辑加入/取消收藏订制/取消短消息举报该贴

可以不要求手性，谢谢！

回复人：claymore,★★★★★ (C-H活化，kumada,suzuki,stille,negishi.cross-coupling.) 时间：2011-08-05 13:34:59 编辑	1楼
http://good.gd/1470602.htm

回复人：qdlct2002,▲▲▲▲ (澳大利亚--我的梦想家园！) 时间：2011-08-05 13:42:14 编辑

2楼

Copyright (c) 1997 American Chemical Society All Rights Reserved.

120:8967
Method of preparing alkylated derivatives of phenylalanine.
Majer, Pavel; Lebl, Michal; Hlavacek, Jan (Czech.). Czech. CS 274337 B1 31 Jul 1992, 5 pp. (Czechoslovakia). CODEN: CZXXA9. CLASS: ICM: C07C229-36. APPLICATION: CS 89-3663 16 Jun 1989. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins)

Sterically hindered phenylalanine derivs. I (R1, R2 = H, C1-4 alkyl; racemic or enantiomeric), useful as uncoded amino acids in peptide analogs (no data), are prepd. by hydrogenolysis of tetrahydroisoquinolinecarboxylic acid derivs. II over Pd black catalysts in AcOH at 100-120°. Thus, hydrogenation of racemic II (R1 = R2 = H) over a 10-20 wt.% Pd sponge as described gave 90% (±)-I (R1 = R2 = H). Analogously, (±)-I (R1 = H, R2 = Me) was prepd. in 65% yield.

回复人：ZHFENG,▲ (精细化工) 时间：2011-08-05 21:38:53 编辑	3楼
已经打分了！

得分人：claymore :3, qdlct2002 :2,

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