问题：请教高人抗乙肝病毒Lumivudine(拉米夫定)原药的熔点和旋光度?
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提问：Ilfruits
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版块：药物化学(jaywoo,合成小象,)
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时间：2005-06-27 14:07:19 编辑加入/取消收藏订制/取消短消息举报该贴

请教高人抗乙肝病毒Lumivudine(拉米夫定)原药的熔点和旋光度?

回复人：chhchem,▲ () 时间：2005-06-28 12:16:05 编辑

1楼

Lamivudine:

CAS Registry Number: 134678-17-4
CAS Name: (2R-cis)-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
Additional Names: (-)-2?deoxy-3?thiacytidine; (-)-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cystosine; 3?thia-2?3?dideoxycytidine; 3TC
Manufacturers' Codes: (-)-BCH-189; GR-109714X
Trademarks: Epivir (Glaxo Wellcome); Zeffix (Glaxo Wellcome)
Molecular Formula: C8H11N3O3S
Molecular Weight: 229.26.
Percent Composition: C 41.91%, H 4.84%, N 18.33%, O 20.94%, S 13.99%
Literature References: Reverse transcriptase inhibitor. Prepn: J. A. V. Coates et al., WO 91 17159 C.A. 117, 111989 (1991). Synthesis of enantiomers: J. W. Beach et al., J. Org. Chem. 57, 2217 (1992); of (-)-enantiomer: D. C. Humber et al., Tetrahedron Letters 33, 4625 (1992). HPLC determn in urine: D. M. Morris, K. Selinger, J. Pharmaceut. Biomed. Anal. 12, 255 (1994). Clinical trial in hepatitis B: F. Nevens et al., Gastroenterology 113, 1258 (1997). Review of pharmacology and clinical efficacy in HIV infection: C. M. Perry, D. Faulds, Drugs 53, 657-680 (1997).
Properties: Crystals from boiling ethanol. mp 160-162? [a]D21 -135?(c = 0.38 in methanol). Soly in water (20?: 70 mg/ml.
Melting point: mp 160-162?
Optical Rotation: [a]D21 -135?(c = 0.38 in methanol)
Therap-Cat: Antiviral.

回复人：Ilfruits,▲▲ () 时间：2005-07-11 20:05:21 编辑	2楼
谢谢chhchem！

回复人：admin,★ (论坛管理员-欢迎大家访问化学化工论坛) 时间：2005-07-11 20:12:49 编辑	3楼
接受答案了。

回复人：bitterpan,▲ () 时间：2007-11-19 18:33:49 编辑	4楼
哥们翻译一下啊不认识啊

得分人：chhchem-1,

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