问题：有人能帮我查到这个东西的合成方法吗？
类型：求助 (悬赏分:3分)
提问：xuezhp
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版块：有机化学问题(jimuwei,fpcwin1211,netpanda,yjgzfl,Ftian,)
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时间：2005-07-29 11:48:49 编辑加入/取消收藏订制/取消短消息举报该贴

2-hydroxy-3-(1-oxopropyl)-benzoic acid
也就是3-乙酰基水杨酸，
这个东西买不到，小人无能没查到合成方法，
有没有高手帮个忙呀

回复人：tangyyer,★★★★★ (有空来逛逛my blog: http://tangyyer.blog.hexun.com) 时间：2005-07-29 23:20:51 编辑

1楼

Entry Name: 3-Acetyl-2-hydroxybenzoic acid
Synonym(s): 3'-Carboxy-2'-hydroxyacetophenone. 3-Acetylsalicylic acid
Chapman Hall Number: FND13-I
CAS Registry Number: 67127-78-0
Structure by analogy with 2-Acetyl-3-hydroxybenzoic acid, FND11-G

Molecular Formula: C9H8O4
Molecular Weight: 180.16
Accurate Mass: 180.04226
Percentage Composition: C 60.00%; H 4.48%; O 35.52%
Physical Description: Cryst. (H2O)
Melting Point: Mp 135-136
References:
Ramsden, C.A. et al., J. Med. Chem., 1986, 29, 538, (synth)

回复人：legend74,▲▲▲▲▲ (刚入门的化工人) 时间：2005-07-30 01:01:32 编辑	2楼
推荐去www.chemsearch.com.cn，这个网站能作CA和Beilstein联合检索，应该能帮助你

回复人：guofeng,▲ () 时间：2005-07-31 09:46:43 编辑

3楼

European Journal of Medicinal Chemistry (1996), 31(11), 861-874
Abstract
A series of 3'- and 5'-carboxylated chalcones, 6- or 8-carboxylated flavones and 6-carboxylated flavanones, -flavanols and -flavans were prepd. The compds. were tested for their inhibitory activities against leukotriene D4 (LTD4) induced contraction of guinea-pig ileum. A new and convenient synthetic route to 3-acetyl-2-hydroxybenzoic acid, a key intermediate for the synthesis of 3'-carboxy-2'-hydroxychalcones and 8-carboxylated flavones, was developed. The activities of the tested compds. ranged from 0 to 63% inhibition at 10-5 M drug concn. against a single challenge of 10-8 M LTD4. Several compds. were tested in a radioligand binding assay against [3H]LTD4 receptors with pKD-values of 4.95 and 4.83, resp., and are interesting lead structures for the development of rigid LTD4 antagonists. In contrast, the rest of the compds. tested in the binding assay did not show significant displacement of the radioligand, implying that for these compds. the functional activity is probably not caused by competitive antagonism at the LTD4 receptor. The exact mechanism of the relaxant activity remains unclear.

回复人：qyl1970,★ (专注于有机合成，接受公斤级化合物定制。) 时间：2005-08-01 11:36:21 编辑	4楼
感觉翻译的名字不对吧.应该是3-丙酰基水杨酸吧.

回复人：unitechem,▲ () 时间：2005-08-04 12:45:54 编辑	5楼
5-乙酰基水杨酸做过三氯化铝与乙酰氯

回复人：xuezhp,▲▲ (我是农民工，我喜欢化学，我在学习化学，快乐的农民工) 时间：2005-08-08 15:42:40 编辑	6楼
接受答案了。

得分人：legend74-1,qyl1970-1,unitechem-1,

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