问题：请教：这个化合物该怎么合成？
类型：求助 (悬赏分:3分)
提问：y9td
等级：▲
版块：有机化学问题(jimuwei,fpcwin1211,netpanda,yjgzfl,Ftian,)
信誉：50%
回复：13
阅读：610
时间：2005-10-12 10:59:31 编辑加入/取消收藏订制/取消短消息举报该贴

这个化合物该怎么合成？
大家都来出出主意！

回复人：januswen,▲▲▲ (漫行漫随漫伫立,亦狂亦侠亦温文) 时间：2005-10-12 12:25:37 编辑	1楼
丙二酸二乙酯在NaH作用下缩合,然后部分还原不知道还原时怎么样反正原料都极便宜,不妨试下

回复人：legend74,▲▲▲▲▲ (刚入门的化工人) 时间：2005-10-12 12:46:39 编辑	2楼
CAS号：95445-50-4 英文名称：6-methoxy-dihydro-pyrimidine-2,4-dione 从CAS号来看这个物质非常新，估计合成的文献不会太多。

回复人：wmx,★ (竹影扫街尘不动，月穿潭水了无痕。) 时间：2005-10-12 13:40:57 编辑	3楼
氰化钠好像不便宜啊

回复人：flychem,★ () 时间：2005-10-12 15:24:43 编辑	4楼
氰化钠毒性太大了。

回复人：y9td,▲ () 时间：2005-10-12 16:58:13 编辑	5楼
legend74 CAS号怎么找到的？我到 NIST化学分子资料库 http://webbook.nist.gov/chemistry/ Springer-Verlag Berlin Heidelberg http://lb.chemie.uni-hamburg.de 都找不到是不是它们不全啊？我还没找到关于这个化合物的一点资料啊

回复人：y9td,▲ () 时间：2005-10-12 17:03:42 编辑	6楼
哪里的CAS比较齐全？

回复人：legend74,▲▲▲▲▲ (刚入门的化工人) 时间：2005-10-12 20:19:22 编辑	7楼
当然是纸本的CA里面最全了，呵呵......

回复人：y9td,▲ () 时间：2005-10-13 13:37:43 编辑	8楼
纸本的CA？查分子式索引？大海捞针啊你是怎么查的？请教一下

回复人：wguoyong,▲▲▲▲ (原来做药物化学的，现在从事表面活性剂/洗涤剂研究开发) 时间：2005-10-13 20:12:15 编辑

9楼

Substance Identifier task started on Thu Oct 13, 2005 at 8:09 PM

Explored by Substance Identifier in REGISTRY.

REGISTRY Answers
1 for 95445-50-4

Get References started for 95445-50-4

1 references were found for 95445-50-4 in CAPLUS and MEDLINE

Copyrights:

CAPLUS: Copyright ?2005 American Chemical Society. All Rights Reserved. (The UK patent material in this product/service is UK Crown copyright and is made available with permission. ?Crown Copyright. The French (FR) patent material in this product/service is made available from Institut National de la Propriete Industrielle (INPI).)
MEDLINE: Produced by the U.S. National Library of Medicine
REGISTRY: Copyright ?2005 American Chemical Society. All Rights Reserved. (Some records contain information from GenBank(R). See also: Benson D.A., Karsch-Mizrachi I., Lipman D.J., Ostell J., Rapp B.A., Wheeler D.L. Genbank. Nucl. Acids Res. 28(1):15-18 (2000). Property values tagged with IC are from the ZIC/VINITI data file provided by InfoChem.)
CASREACT: Copyright ?2005 American Chemical Society. All Rights Reserved. (In addition to reactions indexed by CAS, CASREACT contains reactions derived from the following sources: ZIC/VINITI database (1974-1991) provided by InfoChem, INPI data prior to 1986, and Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich.)
CHEMLIST, CHEMCATS: Copyright ?2005 American Chemical Society. All Rights Reserved.

Bibliographic Information

Synthesis of nucleic acid pyrimidine bases utilizing electrode reaction. Iwasaki, Tameo; Horikawa, Hiroshi; Ozaki, Yasuhiko; Matsumoto, Kazuo. Res. Lab. Appl. Biochem., Tanabe Seiyaku Co., Ltd., Osaka, Japan. Nippon Kagaku Kaishi (1984), (11), 1826-31. CODEN: NKAKB8 ISSN: 0369-4577. Journal written in Japanese. CAN 102:131798 AN 1985:131798 CAPLUS (Copyright (C) 2005 ACS on SciFinder (R))

Abstract

Electrochem. transformations of aspartic acid derivs. into nucleic acid pyrimidine bases were established. The three principal routes were exploited. Dihydroorotic acid which is easily derived from aspartic acid was oxidized anodically to give uracil in a good yield. The method was extended to the synthesis of 1-substituted uracil. To generalize this method, the electrolysis of 5-methyl-5,6-dihydrouracil-5-carboxylic acid which is a positional isomer of dihydroorotic acid deriv. was also carried out to afford thymine in a satisfactory yield. To develop a more practical method, the transformations of asparagine and aspartic acid b-Me ester into uracil were examd. As a result,

回复人：y9td,▲ () 时间：2005-10-14 08:38:01 编辑	10楼
怎么不能加粉了建议给wguoyong加0.1 你用的是光盘CA吧? 我们这里没有啊麻烦你帮我找到原文或告诉我那里可以获取原文万分谢谢! 另外也请教你查文献的技巧那里获得的资料比较新,齐全?

回复人：y9td,▲ () 时间：2005-10-14 08:39:53 编辑	11楼
对上面的兄弟们的回答表示感谢! 但答案还有待完善!

回复人：wguoyong,▲▲▲▲ (原来做药物化学的，现在从事表面活性剂/洗涤剂研究开发) 时间：2005-10-18 22:01:22 编辑	12楼
CA网络版上就这一个

回复人：33888,▲ () 时间：2005-10-19 00:44:03 编辑	13楼
国家化工安全手册里有。你查吧。。

得分人：legend74-1,

问题讨论没有结束...

您尚未进入本论坛,登录之后才可以回贴

8msec