问题：Cefpodoxime proxetil
类型：求助 (悬赏分:3分)
提问：cheman
等级：▲
版块：有机化学资源(yjgzfl,netpanda,)
信誉：50%
回复：4
阅读：1134
时间：2005-11-01 08:25:13 编辑加入/取消收藏订制/取消短消息举报该贴

求Cefpodoxime proxetil的CAS?

回复人：yjgzfl,★ (研究) 时间：2006-01-28 15:24:01 编辑	1楼
已经打分了。

回复人：thinpig7,★ (A chemical freak 作为一名斑竹，坚决反毒！反垃圾广告！) 时间：2005-11-01 08:32:19 编辑

2楼

Derivative: Me ether, 1-[[(1-methylethoxy)carbonyl]oxy]ethyl ester
Synonym(s): Cefpodoxime proxetil
, USAN . Cefmeproxime. Banan. Doxef. Orelox. CS 807. U 76252 Chapman and Hall Number: GRL37-T
CAS Registry Number: 87239-81-4
Type of Compound Code(s): XA1150 XA1200 XA2950 Molecular Formula: C 21 H 27 N 5 O 9 S 2 Molecular Weight: 557.604 Accurate Mass: 557.12502 Percentage Composition: C 45.23%; H 4.88%; N 12.56%; O 25.82%; S 11.50% Use/Importance: Antibacterial agent Physical Description: No phys. props. reported Development Status: Launched 1989 Calculated Log P Data: Log P 0.64 (uncertain value) (calc) Other Data: Prodrug, metab. to parent acid in vivo Hazard and Toxicity: LD 50 (rat, orl) >4000 mg/kg RTECS Accession Number: XI0367370

回复人：chaoming,▲ () 时间：2005-11-01 08:32:25 编辑	3楼
87239-81-4

回复人：chhchem,▲ () 时间：2005-11-02 00:12:48 编辑

4楼

Monograph Number: 1954
Title: Cefpodoxime Proxetil
CAS Registry Number: 87239-81-4
CAS Name: (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-[[(1-methylethoxy)carbonyl]oxy]ethyl ester
Additional Names: 1-(isopropoxycarbonyloxy)ethyl (6R,7R)-7-[2-(2-amino-4-thiazolyl)-(Z)-2-(methoxyimino)acetamido]-3-methoxymethyl-3-cephem-4-carboxylate
Manufacturers' Codes: CS-807; U-76252
Trademarks: Banan (Sankyo); Cefodox (Aventis); Orelox (Aventis); Otreon (Luitpold); Vantin (Pharmacia & Upjohn)
Molecular Formula: C21H27N5O9S2
Molecular Weight: 557.60.
Percent Composition: C 45.24%, H 4.88%, N 12.56%, O 25.82%, S 11.50%
Literature References: Broad spectrum, orally absorbed third generation cephalosporin, ester prodrug of the active free acid metabolite, cefpodoxime. Prepn: H. Nakao et al., EP 49118; eidem, US 4486425 (1982, 1984 both to Sankyo). Prepn, pharmacokinetics and NMR analysis: K. Fujimoto et al., J. Antibiot. 40, 370 (1987). In vitro and in vivo antibacterial activity: Y. Utsui et al., Antimicrob. Ag. Chemother. 31, 1085 (1987). In vitro antibacterial spectrum and susceptibility testing of free acid: R. N. Jones, A. L. Barry, ibid. 32, 443 (1988). Series of articles on antibacterial spectrum, pharmacokinetics, toxicology and clinical studies: Chemotherapy (Tokyo) 36, Suppl. 1, 1-1126 (1988). Symposium on pharmacokinetics and clinical efficacy: J. Antimicrob. Chemother. 26, Suppl. E, 1-101 (1990). Review of chemistry, antibacterial activity, toxicity and clinical studies: H. Nakao et al., Sankyo Kenkyusho Nempo 39, 1-44 (1987), C.A. 109, 27503x (1988).
Properties: LD50 in male, female mice, male, female rats (mg/kg): >10000, >10000, >2000, >2000 s.c., 3502, 2535, >4000, >4000 i.p.; >8000, >8000, >4000, >4000 orally (Nakao, 1988).
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): >10000, >10000, >2000, >2000 s.c., 3502, 2535, >4000, >4000 i.p.; >8000, >8000, >4000, >4000 orally (Nakao, 1988)

得分人：thinpig7-1,

问题讨论没有结束...

您尚未进入本论坛,登录之后才可以回贴

6msec